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cainiaodui

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The “tip” cell, located at the leading edge of an angiogenic sprout, is highly migratory as evident by the presence of filopodia and expresses high levels of VEGFR-2, VEGFR-3, and platelet-derived growth factor-B. In the retina, the tip cells are thought to require high levels of VEGFR-2 to migrate toward a VEGF gradient produced by the underlying astrocyte plane.The “stalk” cell, located adjacent to the tip cell, is proliferative and lumenizing, and it expresses high levels of VEGFR-1. The cellular mechanisms that differentiate a lumenizing stalk cell from a proliferative stalk cell have yet to be elucidated.
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conf20140319

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RXMCDM: 屏蔽内容 2014-04-25 15:35:07
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