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| If VEGF-A induces tip cell formation, it is surprising to see that tip cells are normally not formed by adjacent endothelial cells but form at characteristic intervals, enabling adequately spaced branching and sprouting. The molecular mechanism responsible for the fact that not all endothelial cells stimulated by VEGF become tip cells is based on the activity of Dll4/Notch signaling. |
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cainiaodui: ½ð±Ò+5, ·ÒëEPI+1 2014-03-31 15:44:20
cainiaodui: ½ð±Ò+5, ·ÒëEPI+1 2014-03-31 15:44:20
| Èç¹û˵Ѫ¹ÜÄÚÆ¤Éú³¤Òò×Ó-A£¨vascular endothelial growth factor£¬VEGF£©ÓÕµ¼ÄÚÆ¤¼â¶Ëϸ°ûÐγɣ¬ÁîÈ˾ªÑȵÄÊÇ£¬ÄÚÆ¤¼â¶Ëϸ°ûͨ³£²»ÊÇÏàÁÚµÄÄÚÆ¤Ï¸°ûÐγɵģ¬È´ÊÇÔÚÌØ¶¨µÄÉÏÆ¤Ï¸°û¼ä¸ôÖ®¼äÐγɣ¬ÉÏÆ¤Ï¸°û¼ä¸ôÓÐ×ã¹»µÄ¿Õ¼äʹ·ÖÖ¦Ó뷢ѿ³ÉΪ¿ÉÄÜ¡£²¢·ÇËùÓÐVEGF´Ì¼¤µÄÉÏÆ¤Ï¸°û¶¼·Ö»¯³ÉÉÏÆ¤¼â¶Ëϸ°ûµÄÊÇÒòΪ»ùÓÚDll4/NotchÐźŻîÐÔ²»Í¬²úÉúÁ˲»Í¬µÄ·Ö×Ó»úÖÆ¡£ |

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