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【转/分享】07年的一篇RNA干扰的最新review
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这篇文章是我在中国生命科学论坛找到的，在这里把它转过来，希望没有在那里注册的朋友能分享。不过还是希望大家去顶下帖，尊重原帖作者的劳动。 http://www.bioon.net/viewthread.php?tid=258976 请版主注意，非广告  。下载地址：http://www.91files.com/?03NCHO629NXJY26OQ3HL 文献相关信息： RNAi信息在细胞间传递（年鉴级的综述） When eukaryotic cells encounter double-stranded RNA, genes of matching sequence are silenced through RNA interference. Surprisingly, in some animals and plants, the same gene is specifically silenced even in cells that did not encounter the double-stranded RNA, due to the transport of a gene-specific silencing signal between cells. This silencing signal likely has anRNAcomponent that gives it sequence-specificity, however its precise identity remains unknown. Studies in the worm Caenorhabditis elegans and in plants have revealed parts of a complex protein machinery that transports this silencing signal. Some of these proteins are conserved in vertebrates, including mammals, raising the possibility that higher animals can communicate gene-specific silencing information between cells. Such communication provides antiviral immunity in plants and perhaps in C. elegans. Identifying the transported silencing signal and deciphering the evolutionarily selected role of the transport machinery are some of the key challenges for the future. [ Last edited by bsksln on 2008-2-21 at 23:21 ] |
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