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[资源] Acc. Chem. Res.最新综述：Switchable Host−Guest Systems on Surfaces

Switchable Host − Guest Systems on Surfaces
共11页引文54篇
CONSPECTUS: For device miniaturization, nanotechnology follows either the “ top-down ” approach scaling down existing
larger-scale devices or the “ bottom-up ’ approach assembling the smallest possible building blocks to functional nanoscale
entities. For synthetic nanodevices, self-assembly on surfaces is a superb method to achieve useful functions and enable their
interactions with the surrounding world. Consequently, adaptability and responsiveness to external stimuli are other
prerequisites for their successful operation. Mechanically interlocked molecules such as rotaxanes and catenanes, and
their precursors, that is, molecular switches and supramolecular switches including pseudorotaxanes, are molecular
machines or prototypes of machines capable of mechanical motion induced by chemical signals, biological inputs, light or redox
processes as the external stimuli. Switching of these functional host − guest systems on surfaces becomes a fundamental
requirement for arti ﬁ cial molecular machines to work, mimicking the molecular machines in nature, such as proteins and their
assemblies operating at dynamic interfaces such as the surfaces of cell membranes. Current research endeavors in material science
and technology are focused on developing either a new class of materials or materials with novel/multiple functionalities by
shifting host − guest chemistry from solution phase to surfaces.
In this Account, we present our most recent attempts of building monolayers of rotaxanes/pseudorotaxanes on surfaces,
providing stimuli-induced macroscopic e ﬀ ects and further understanding on the switchable host − guest systems at interfaces.
Biocompatible versions of molecular machines based on synthetic macrocycles, such as cucurbiturils, pillararenes, calixarenes, and
cyclodextrins, have been employed to form self-assembled monolayers of gates on the surfaces of mesoporous silica nanoparticles
to regulate the controlled release of cargo/drug molecules under a range of external stimuli, such as light, pH variations,
competitive binding, and enzyme. Rotaxanes have also been assembled onto the surfaces of gold nanodisks and microcantilevers
to realize active molecular plasmonics and synthetic molecular actuators for device fabrication and function. Pillararenes have
been successfully used to control and aid the synthesis of gold nanoparticles, semiconducting quantum dots, and magnetic
nanoparticles. The resulting organic − inorganic hydrid nanomaterials have been successfully used for controlled self-assembly,
herbicide sensing and detection, pesticide removal, and so forth, taking advantage of the selective binding of pillarenes toward
target molecules. Cyclodextrins have also been successfully functionalized onto the surface of gold nanoparticles to serve as
recycling extractors for C 60 . Many interesting prototypes of nanodevices based on synthetic macrocycles and their host − guest
chemistry have been constructed and served for di ﬀ erent potential applications. This Account will be a summary of the e ﬀ orts
made mainly by us, and others, on the host − guest chemistry of synthetic macrocyclic compounds on the surfaces of di ﬀ erent
solid supports.

Biography
Ying-Wei Yang received his degrees (B.Sc. in 2000, Ph.D. in 2005) from Nankai University. He gained postdoctoral training at ASU, UCLA, and UC Irvine (2005–2010). Since 2011, he became an Associate Professor in the College of Chemistry at Jilin University. He is also an Adjunct Professor at Shenyang Pharmaceutical University. His research interests include organic supramolecular chemistry and stimuli-responsive polymers.
Biography
Yu-Long Sun was born in 1988 in Liaoning, China. He obtained his B.E. in Pharmaceutical Engineering in 2011 from Harbin University of Science and Technology, China. Then, he joined Professor Ying-Wei Yang’s group at Jilin University. He was a visiting researcher in the Stoddart group at Northwestern University during March to August, 2013.
Biography
Nan Song was born in 1991 in Henan, China and grew up in Lanzhou, China. She attended Jilin University for her undergraduate studies and completed her B.Sc. in Chemistry in 2013, where she performed research under the direction of Professor Ying-Wei Yang. She is currently a M.S. student in the same research group.

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