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yanzhang722木虫 (正式写手)
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从毛冬青干燥根的乙醇提取物中，利用硅胶柱和D101大孔树脂等色谱手段分离得到 18个化合物；其中有5个乌苏烷型五环三萜皂甙化合物，二个五环三萜化合物，还有一些酚甙类化合物。 药理研究表明，脉络宁新组方药的水提醇沉样（A），在抗血小板聚集实验中表现了很好的活性，且效果优于阳性对照脉络宁注射液及阿斯匹林。在对脉管炎的影响实验中，A样也表现出很好的活性。但是，急性毒性试验显示其毒性较大。但是从A样中分离得到的化合物No.1显示毒性很小，同时，抗血栓实验结果显示：化合物No.1和A样一样在高、中、低剂量时都能明显减少大鼠肝气郁结和寒凝血瘀证血栓的形成，与模型组比较使血栓重量减少27～35%（p<0.05～0.01），其抗血栓作用与脉络宁相当，说明化合物No.1和A样对血瘀症大鼠血小板聚集有一定抑制作用。以上研究表明脉络宁新组方药显示了较好的开发前景。 |
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木虫 (著名写手)
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yanzhang722(金币+5,VIP+0):xiexie
yanzhang722(金币+5,VIP+0):xiexie
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觉得好，给金币哦！ From in the wool Chinese ilex dry root ethyl alcohol extraction, using chromatograph method separations and so on silica gel column and D101 pocket resin obtains 18 compound; In which has 5 Wusu alkane five link three tie soap glucoside compound, two five link three tie compound, but also has some phenol glucoside class compound. The pharmacology research indicated that, the vein rather new group Fang Yao water raises sinks mellowly type (A), has displayed the very good activeness in the anti-blood platelet accumulation experiment, also the effect surpasses the masculine comparison vein rather inoculation fluid and the aspirin.In to the vasculitis in the influence experiment, A type also displays the very good activeness.But, the acute toxicity test demonstrated its toxicity is big.But from the compound No.1 demonstration toxicity which A type separations obtain is very small, simultaneously, the anti-thrombus experiment result showed: Compound No.1 and A type equally when high, low dose all can reduce the big mouse vital energy of the liver obviously depressed and the cold hemoglutination stasis card thrombus formation, compares with the model group causes the thrombus weight to reduce 27~35% (p< 0.05~0.01), its anti-thrombus function and the vein rather quite, showed compound No.1 and A type have certain inhibitory action to the blood stasis sickness big mouse blood platelet accumulation.Above research indicated the vein rather new group side medicine has demonstrated the good development prospect. |
2楼2008-02-23 20:43:18