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【答案】应助回帖
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RXMCDM: 金币+1, 多谢应助！ 2014-03-14 00:56:23
wzg389960: 金币+20, 翻译EPI+1, ★★★很有帮助 2014-03-15 05:21:46
GSTs are divided into two groups: the membrane-bound microsomal and the cytosolic GSTs.
GST被分为两组：膜结合的微粒体GST和胞浆GST。
Microsomal GSTs exist in homo- and hetero-trimerized forms with a single active site and function in the endogenous metabolism of leucotrienes and prostaglandins [8].
微粒体GST以同三聚体或异三聚体形式存在，它只有一个活性中心，并在白细胞三烯和前列腺素的胞内代谢中起作用。
In humans, cytosolic GSTs exist in the form of various dimerized isoenzyme classes: (A), μ (M), , (P), (T), (Z) and classes[8,13].
在人类中，胞浆GST以多种二聚体同工酶形式存在：（略）。
Their existence in different forms has provided broad substrate specificities promoting detoxification of many toxic substances.
不同形式的胞浆GST的存在为其提供了宽泛的特异性底物范围，这促进了许多种有毒底物的解毒作用。
Recently, the X-ray crystal structure of GST of the malaria-causing parasite, Plasmodium falciparum, was elucidated [14].
最近导致疟疾的寄生虫——恶性疟原虫的GST的X射线晶体结构得到了阐明。
The isoenzymes of GST are related in their aminoacid constituents and a little in their conformation except at specific regions, two of which are needed for activity.
GST的同工酶在其氨基酸组成上相互关联，除了在特定区域之外，其构象也相互关联，其中两个特定区域对于其活性是必需的。
This distinguishing uniqueness is attributed to the catalytic hydrophobic site (H-site) and a glutathione-binding site (G-site), which offer diversity in specificities of the different isoenzymes for different substrates.
这种造成区别的独特性属于催化性的疏水位点（H位点）和一个谷胱甘肽结合位点（G位点），它们为不同同工酶对不同底物的特异性提供了多样性。
In addition to their xenobiotic detoxification roles, human and parasitic GSTs have been implicated as lead actors in cellular drug resistances, which is a major factor in the failure of chemotherapy [15].
除了对异生物质的解读作用之外，人类和寄生虫的GST也是细胞的药物抗性的首要作用物质，而这正是化学疗法失效的主要因素。
Electrophilic alkylating anticancer and antiparasitic drugs have been reported to be either substrates or ligands for the different GST isoenzymes [16], and this forms the basis of cellular drug resistances.
据报道，亲电子烷化抗癌和抗寄生虫药物可以充当不同GST同工酶的底物或配体，这一现象构成了细胞药物抗性的基础。 |
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