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What is important, administration of DLL4 neutralizing antibody was probably responsible for rapid changes in mouse liver gene expression associated with proliferation and cell cycle regulation. Moreover, animals models such as mice, rats and cynomolgus monkeys exposed to anti-DLL4 antibody have developed strong changes in the liver tissue including profound sinusoidal dilation and centrilobular hepatocyte atrophy. It is thought that those changes were the effect of DLL4 inhibition through Notch1 receptor.
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真强必胜: 金币+1, 谢谢 2014-03-05 15:12:55
cainiaodui: 金币+5, 翻译EPI+1 2014-03-05 21:20:09
重要的是,DLL4中和抗体给药,可能引起与增殖和细胞周期调控相关的小鼠肝脏基因表达的快速变化。此外,动物模型如小鼠,大鼠和食蟹猴暴露于抗DLL4抗体已有产生肝组织巨大改变,包括广泛肝窦扩张( sinusoidal dilatation)和小叶中心肝细胞萎缩。普遍认为这些变化是通过Notch1受体的作用抑制了DLL4的结果。
2楼2014-03-01 01:04:07
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