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《化学前沿》2011年11月（英文版）－Thomson Reuters
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IN THIS ISSUE The nutlins were first identified by scientists screening a chemical library at Hoffmann-La Roche. In this article, we showcase a new synthetic route to (-)-nutlin 3 recently developed by Tyler Davis and Jeffrey Johnston of Vanderbilt University, that paves the way into the enantioselective arena of nutlin synthesis. A wide range of new skeletons emphasize that novel chemical scaffolds with biological activity underpin major advances in medicinal chemistry. New molecular mechanisms of action are disclosed for a variety of indications. This issue includes drugs related to diabetes, cancer and other conditions such as Graves’ disease and multiple sclerosis. In this report, we look at how the downsizing pharmaceutical industry is generating new opportunities for the smaller biotechnology and discovery companies. Collaborations between large pharma companies and these smaller enterprises, and even university departments and their spin-off companies, can help cut the overall risk exposure as well as lower investment costs significantly through a focus on developing only those drugs emerging from small laboratories that already show a great deal of clinical promise. Further to this article, Thomson Reuters has produced a report commemorating the 2011 International Year of Chemistry, titled “The Changing Role of Chemistry in Drug Discovery”. The report explores the themes of this article in greater depth, with the input from many key pharmaceutical industry players, and examines how life in drug discovery has changed and how it will continue to change and adapt in the future. |
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2014-02-27 09:31:25, 472.51 K
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ald2楼
2014-04-22 22:42
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五星好评 顶一下，感谢分享！
