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[求助]
异丙醚和叔丁醇毒理学研究的标准文献
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各位大神： 小弟目前在做原料药中异丙醚和叔丁醇的残留，但药典上并未给出这两种溶剂的限度，不知各位在做的时候是如何定的限度？有没有相关毒理学研究的标准文献？ |
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lunar3809
荣誉版主 (文坛精英)
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叔丁醇的急毒！ Toxicity Organism Test Type Route Reported Dose (Normalized Dose) Effect Source frog LDLo parenteral 12gm/kg (12000mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 50, Pg. 296, 1935. guinea pig LD50 skin > 10mL/kg (10mL/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" National Technical Information Service. Vol. OTS0556680, mouse LD50 intraperitoneal 399mg/kg (399mg/kg) LIVER: OTHER CHANGES Research Communications in Chemical Pathology and Pharmacology. Vol. 26, Pg. 75, 1979. Link to PubMed mouse LD50 intravenous 1538mg/kg (1538mg/kg) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 330, 1962. Link to PubMed rabbit LD50 oral 3559mg/kg (3559mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: PULSE RATE SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE Industrial Medicine and Surgery. Vol. 41, Pg. 31, 1972. rabbit LD50 skin > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" National Technical Information Service. Vol. OTS0572351, rat LC50 inhalation > 10000ppm/4H (10000ppm) LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA National Technical Information Service. Vol. OTS0572351, rat LD50 oral 2743mg/kg (2743mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION National Technical Information Service. Vol. OTS0572351, |
3楼2014-01-18 14:09:52
lunar3809
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异丙醚 mammal (species unspecified) LC50 inhalation 130gm/m3 (130000mg/m3) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988. mammal (species unspecified) LD50 oral 6gm/kg (6000mg/kg) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988. mouse LC50 inhalation 131gm/m3 (131000mg/m3) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: GENERAL ANESTHETIC Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 19(10), Pg. 55, 1975. mouse LD50 intraperitoneal 812mg/kg (812mg/kg) Shell Chemical Company. Unpublished Report. Vol. -, Pg. 5, 1961. mouse LD50 unreported 3600mg/kg (3600mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 19(10), Pg. 55, 1975. rabbit LC50 inhalation 121gm/m3 (121000mg/m3) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 19(10), Pg. 55, 1975. rabbit LD50 skin 20mL/kg (20mL/kg) Union Carbide Data Sheet. Vol. 4/10/1968, rabbit LDLo oral 6gm/kg (6000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Industrial Hygiene and Toxicology. Vol. 21(3), Pg. 72, 1939. rat LC50 inhalation 162gm/m3 (162000mg/m3) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 19(10), Pg. 55, 1975. rat LD50 oral 8470mg/kg (8470mg/kg) Union Carbide Data Sheet. Vol. 4/10/1968, rat LD50 unreported 5880mg/kg (5880mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 19(10), Pg. 55, 1975. |
2楼2014-01-18 14:01:54
