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| The initial speculation of DLL4 signaling involvement in tumor angiogenesis came from expression analyses of DLL4. Results from a flurry of recent studies confirmed that targeting DLL4/NOTCH1 signaling has a profound impact on tumor angiogenesis and growth.Pathway blockade was achieved using either a DLL4-selective neutralizing antibody , a NOTCH1-selective antagonistic antibody, a soluble DLL4 fusion protein, or a soluble NOTCH fusion protein. These reagents demonstrated broad and robust anti-tumor activity in a wide variety of tumor models. |
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| DLL4£¨Delta like ligand 4£¬µÂ¶ûËþÑùÅäÌå4£©ÐźŲÎÓëÖ×ÁöѪ¹ÜÉú³ÉµÄ×î³õÍÆ²âÀ´×ÔDLL4µÄ±í´ï·ÖÎö¡£×î½üµÄÑо¿Ö¤Êµ£¬°ÐÏòDLL4/NOTCH1ÐźŶÔÖ×ÁöѪ¹ÜÉú³ÉºÍÔö³¤²úÉúÉîÔ¶µÄÓ°Ï졣ͨ·×èÖÍ¿ÉʹÓÃDLL4Ñ¡ÔñÐÔÖкͿ¹Ì壬NOTCH1Ñ¡ÔñÐÔÞ׿¹£¨¾ºÕù£©ÐÔ¿¹Ì壬¿ÉÈÜÐÔDLL4Èںϵ°°×»ò¿ÉÈÜÐÔNOTCHÈںϵ°°×ʵÏÖ¡£ÕâЩÊÔ¼Á¾Ö¤ÊµÔÚ¶àÖÖÖ×ÁöÄ£Ð;ßÓй㷺ºÍÇ¿´óµÄ¿¹Ö×Áö»îÐÔ¡£ |

2Â¥2014-01-04 23:07:21
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3Â¥2014-01-04 23:17:08
RXMCDM
°æÖ÷ (ÎÄ̳¾«Ó¢)
- ·ÒëEPI: 530
- Ó¦Öú: 401 (˶ʿ)
- ¹ó±ö: 1.908
- ½ð±Ò: 38947.6
- É¢½ð: 4908
- ºì»¨: 88
- ɳ·¢: 4
- Ìû×Ó: 11453
- ÔÚÏß: 1355.6Сʱ
- ³æºÅ: 2739168
- ×¢²á: 2013-10-20
- ÐÔ±ð: GG
- רҵ: Ò»°ã¹ÜÀíÀíÂÛÓëÑо¿·½·¨ÂÛ
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4Â¥2014-01-04 23:18:12














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