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Joullie and Richard developed a system of nomenclature that classifies peptide alkaloids as: (i) cyclopeptide alkaloids sensu stricto, which exhibit basic properties due to a peptidogenic amino acid with an N-mono-methyl or N,Ndimethylated side-chain; (ii) linear peptide alkaloids; and (iii) neutral cyclopeptides, which do not exhibit a peptidogenic amino acid with an N-mono-methyl or N,N-dimethylated side chain。
Currently, only eight compounds representative of the latter category have been isolated and characterized,and three of them are named with the ending ene, as scutianene C (=scutianene D) (Sierra et al., 1974), discarenes C and D(Giacomelli et al., 2001), while the others end in ine, as discarines M and N (Giacomelli et al., 2004), lotusanine B, sanjoinenine (Han et al., 1989; Abu-Zarga et al., 1995), and amaiounine (Oliveira et al.,2009). Therefore, in this work we use the termination ene, featuring a double bond, and not the ending ine, used to denominate cyclopeptide alkaloids sensu stricto.
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