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【答案】应助回帖
放弃是对的，总的来说，它是一种试验性治疗，不值得，详见：
The Role of Adoptive Cell Therapy in Cancer Immunotherapy
Immunotherapy for the treatment of human cancer falls into three major categories. Nonspecific approaches to cancer treatment involves the administration of cytokines such as interleukin 2 (IL-2) that can activate immune effector cells. Alternatively, the introduction of an antibody that blocks inhibitory molecules such as CTLA4 on the lymphocyte surface can also activate antitumor immune effectors. The second major category of cancer immunotherapies involves active immunization or 鈥渃ancer vaccines.鈥 Although this represents a very attractive approach to cancer treatment because of its simplicity and ease of administration, there are currently no active immunization approaches that are capable of mediating the regression of established human cancer in all but the most sporadic of cases.3 The third approach, ACT, is the subject of this chapter. ACT has been shown to be effective in the treatment of patients with metastatic melanoma as well as in patients with posttransplant lymphoproliferative disease (PTLD) and virally induced cancers.
ACT has a variety of advantages compared to other forms of cancer immunotherapy.4 T lymphocytes, once identified as cancer reactive, can be expanded to large numbers in vitro using cytokine growth factors. Thus, patients can be administered very large numbers of cells, often much larger than can be naturally generated in vivo. These antitumor lymphocytes can be activated in vitro to express appropriate effector functions such as the ability to lyse tumor cells and secrete cytokines. Secreted cytokines can have a variety of secondary antitumor effects at the cancer site such as the destruction of surrounding blood vessels, the direct lysis of tumor cells and providing chemokine signals to attract additional effector cell types, such as activated macrophages, to the tumor site. Perhaps most important, when using ACT it is possible to modify the host to enhance the ability of the infused cells to establish, grow, and function in vivo. The ability to immunosuppress the host prior to cell infusion is unique to ACT. Immunosuppression can counteract the impact of T-regulatory cells that can suppress cellular immune reactions as well as remove other endogenous lymphocytes that compete with the infused cells for homeostatic cytokines such as IL-7 and IL-15, which are necessary for antitumor T-cell expansion in vivo.
中国的这类试验性治疗，你懂得！ |
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