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[求助]
求助！请问现在临床上CIK或者DC-CIK疗法治疗癌症的效果如何？ 已有6人参与
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家里人牙龈上复发癌症了，治疗到现在已经花了不少钱。对于接下来的治疗，我们希望能把钱花在真正有用的治疗方案上。 医生推荐了一种“自身免疫细胞疗法”简称应该是CIK或者DC-CIK吧。有人了解这种疗法的疗效吗？我们该采用这种疗法吗？ 请确定应助的虫友拿出可靠证据证明您的观点。您的建议可能会决定我们家庭的未来。 |
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zhairuidd
金虫 (小有名气)
- 应助: 1 (幼儿园)
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- 注册: 2013-05-30
- 性别: GG
- 专业: 泌尿系统疾病诊疗新技术
【答案】应助回帖
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放弃是对的，总的来说，它是一种试验性治疗，不值得，详见： The Role of Adoptive Cell Therapy in Cancer Immunotherapy Immunotherapy for the treatment of human cancer falls into three major categories. Nonspecific approaches to cancer treatment involves the administration of cytokines such as interleukin 2 (IL-2) that can activate immune effector cells. Alternatively, the introduction of an antibody that blocks inhibitory molecules such as CTLA4 on the lymphocyte surface can also activate antitumor immune effectors. The second major category of cancer immunotherapies involves active immunization or 鈥渃ancer vaccines.鈥 Although this represents a very attractive approach to cancer treatment because of its simplicity and ease of administration, there are currently no active immunization approaches that are capable of mediating the regression of established human cancer in all but the most sporadic of cases.3 The third approach, ACT, is the subject of this chapter. ACT has been shown to be effective in the treatment of patients with metastatic melanoma as well as in patients with posttransplant lymphoproliferative disease (PTLD) and virally induced cancers. ACT has a variety of advantages compared to other forms of cancer immunotherapy.4 T lymphocytes, once identified as cancer reactive, can be expanded to large numbers in vitro using cytokine growth factors. Thus, patients can be administered very large numbers of cells, often much larger than can be naturally generated in vivo. These antitumor lymphocytes can be activated in vitro to express appropriate effector functions such as the ability to lyse tumor cells and secrete cytokines. Secreted cytokines can have a variety of secondary antitumor effects at the cancer site such as the destruction of surrounding blood vessels, the direct lysis of tumor cells and providing chemokine signals to attract additional effector cell types, such as activated macrophages, to the tumor site. Perhaps most important, when using ACT it is possible to modify the host to enhance the ability of the infused cells to establish, grow, and function in vivo. The ability to immunosuppress the host prior to cell infusion is unique to ACT. Immunosuppression can counteract the impact of T-regulatory cells that can suppress cellular immune reactions as well as remove other endogenous lymphocytes that compete with the infused cells for homeostatic cytokines such as IL-7 and IL-15, which are necessary for antitumor T-cell expansion in vivo. 中国的这类试验性治疗，你懂得！ |
11楼2014-10-03 16:44:30
why82414
铜虫 (小有名气)
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- 专业: 肿瘤物理治疗
2楼2013-12-19 11:21:42
3楼2013-12-19 20:10:27
tomorrow2099
新虫 (小有名气)
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- 专业: 肿瘤生物治疗
【答案】应助回帖
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楼主你说的是肿瘤生物治疗，现在很多医院都开设生物治疗科或细胞治疗中心，现在说的生物治疗主要是细胞层面的，基因靶向和分子靶向还处于临床实验阶段，并没有形成成熟的方案，其实细胞免疫治疗本身也存在很多问题，有可能引起肿瘤细胞逃逸，一旦发生逃逸，基本就没用了。生物治疗是21世纪新兴的技术，也是目前肿瘤治疗研究最热门的研究，细胞免疫治疗已发展的相对完善，你说的dc cikdc，都是体内天然的免疫杀伤细胞，能识别肿瘤细胞并杀死肿瘤细胞，都是在体内提取dc cik 细胞，在体外经il-2等的诱导下培养增值然后回输到患者体内，细胞免疫治疗现在并不能解决所有的肿瘤，对某些肿瘤具有很好的治疗效果，像你亲人的这种可以试试。 [ 发自手机版 http://muchong.com/3g ] |
4楼2013-12-22 23:08:03