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ludasheng-1

金虫 (小有名气)


[资源] Cancer Proteomics: From Bench to Bedside (Cancer Drug Discovery and Development)


Cancer Proteomics: From Bench to Bedside (Cancer Drug Discovery and Development)
By Sayed S. Daoud

Publisher: Humana Press
Number Of Pages: 300
Publication Date: 2007-11-13
ISBN-10 / ASIN: 1588298582
ISBN-13 / EAN: 9781588298584
Binding: Hardcover




This book provides the reader with broad perspectives and breadth of knowledge on current topics related to the use of proteomic strategies in cancer therapy as well as anticipated challenges that may arise from its application in daily practice. The book is divided into 4 parts. The first part begins with the current technologies used in proteomics that allow for protein profiling and for the identification of druggable targets in human samples. Mass spectrometry based protein characterization and protein microarrays hold great promise of predicting response to specific drugs in cancer therapy. The second part deals with the use proteomics in cell signaling. At the present, the pharmaceutical and biotechnology industries have many potentially useful small molecule inhibitors of many pathways important in cancer that have yet to be taken to clinical trials. Understanding protein-protein interaction and posttranslational modifications through proteomics will likely make it much more feasible to do effective clinical trials of these small molecules alone and in combinations to overcome drug resistance and improve patient care. The third part of the book moves from signaling to actual clinical applications of proteomics in cancer therapy. Case studies in may tumor types are provided to show the feasibility of generating the critical information needed to individualization of therapy in cancer patients. The final part of the book provides in depth information on annotating the human proteome and the role of Food and Drug Administration (FDA) in regulating the use of proteomics in cancer therapy. To functionally annotate the human proteome, the Swiss Institute for Bioinformatics (SIB) and the European Bioinformatics Institute (EBI) initiated a major effort to distribute to the scientific community highly integrated information on human protein sequences. This initiative, which is called the Human Proteomics Initiative (HPI) aims to provide for each known human protein a wealth of information that include the description of its function, domain and protein family classification, subcellular location, posttranslational modifications, variants and similarities to other proteins. Integration of bioinformatics into clinical application of proteomics in cancer therapy is outlined as well as regulations and policy of commercial application of proteomics in patient care.

Link:
http://rapidshare.com/files/79603386/asd_Cancer_Proteomics.rar
http://www.megaupload.com/?d=TSQS7G6L
http://w15.easy-share.com/13439551.html
http://depositfiles.com/files/2867982
http://rapidshare.com/files/7968 ... .bioXplorer.com.rar
[search]Cancer Proteomics[/search]
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chenxianmin

银虫 (小有名气)


谢谢楼主,下不了。能不能给我发一份啊

5楼2008-02-21 21:28:54
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清风过

至尊木虫 (职业作家)


thanks for share
2楼2007-12-30 05:54:04
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wanzhongli

木虫 (正式写手)


★★★★★ 五星级,优秀推荐

非常感谢您的辛勤劳动!
3楼2007-12-30 09:07:34
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dnazyme

捐助贵宾 (知名作家)


★★★ 三星级,支持鼓励

【评价】★★★★★ (五星级,优秀推荐)

非常感谢您的辛勤劳动!
4楼2007-12-30 09:30:31
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