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Yinsheng Wang@UCR

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【导师姓名】Yinsheng Wang
【研究方向】Oxidative DNA Damage；Post-translational Modifications of HMG Proteins
【所在单位】Department of Chemistry
               University of California at Riverside
               Labs: Physical Sciences I, 339, 341, 343, 345, 347
               Lab Phone Numbers: (951)827-2593, 2701

【研究成果】Publications
2007

Zhang, Q. and Wang, Y.* Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity.  J. Proteome Res., 2007, 6, in press.

Hong, H.; Cao, H. and Wang, Y.* Formation and genotoxicity of a guanine-cytosine intrastrand cross-link lesion in vivo.  Nucleic Acids Res., 2007, 35, in press.

Jiang, Y.; Hong, H.; Cao, H. and Wang, Y.*  In-vivo formation and in-vitro replication of a guanine-thymine intrastrand cross-link lesion.  Biochemistry, 2007, 46, in press.

Gao, Y. and Wang, Y.* A method to determine the ionization efficiency change of peptides caused by phosphorylation.  J. Am. Soc. Mass Spectrom., 2007, 19, in press.

Cao, H.; Jiang, Y. and Wang, Y.*  Stereospecific synthesis and characterizations of oligodeoxyribonucleotides containing N2-(1-carboxyethyl)-2’-deoxyguanosine.  J. Am. Chem. Soc, 2007, 129, 12123-12130.

Zhang, Q.; Zhang, K.; Zou, Y.; Perna, A. D. and Wang, Y.* A quantitative study on the in-vitro and in-vivo acetylation of high mobility group A1 proteins.  J. Am. Soc. Mass Spectrom., 2007, 19, 1569-1578.

Cao, H. and Wang, Y.* Quantification of oxidative single-base and intrastrand cross-link lesions in unmethylated and CpG-methylated DNA induced by Fenton-type reagents.  Nucleic Acids Res., 2007, 35, 4833-4844.

Men, L. and Wang, Y.* The oxidation of yeast alcohol dehydrogenase-1 by hydrogen peroxide in vitro.  J. Proteome Res., 2007, 6, 216-225.

Hong, H. and Wang, Y.* Derivatization with Girard reagent T combined with LC-MS/MS for the sensitive detection of 5-formyl-2’-deoxyuridine in cellular DNA.  Anal. Chem., 2007, 79, 322-326.

Zou, Y.; Wang, Y.* Mass spectrometric analysis of high-mobility group proteins and their post-translational modifications in normal and cancerous human breast tissues.  J. Proteome Res. 2007, 6, 2304-2314.

Gu, C.; Wang, Y.*  In-vitro replication and thermodynamic studies of methylation and oxidation modifications of 6-thioguanine.  Nucleic Acids Res., 2007, 35, 3693-3704.

Zou, Y.; Webb, K.; Perna, A. D.; Zhang, Q.; Clarke, S.; and Wang, Y.*  A mass spectrometric study on the in-vitro methylation of HMGA1a and HMGA1b proteins by PRMTs:  methylation specificity, the effect of binding to AT-rich duplex DNA and the effect of C-terminal phosphorylation.  Biochemistry, 2007, 46, 7896-7906.

Zeng, Y. and Wang, Y.*  UVB-induced formation of intrastrand crosslink products of DNA in MCF-7 cells treated with 5-bromo-2’-deoxyuridine.  Biochemistry, 2007, 46, 8189-8195.

Qiu, H. and Wang, Y.* Probing adenosine nucleotide-binding proteins with an affinity labeled-nucleotide probe and mass spectrometry.  Anal. Chem., 2007, 79, 5547-5556.

Jiang, D; Men, L.; Wang, J.; Zhang, Y; Chickenyen, S.; Wang, Y. and Zhou, F.* Redox reactions of copper complexes formed with different b-amyloid peptides and their neuropathalogical relevance. Biochemistry, 2007, 46, 9270-9282.

Men, L.; Roginskaya, M.; Zou, Y. and Wang, Y.* Redox-dependent formation of disulfide bonds in human replication protein A.  Rapid Commun. Mass Spectrom., 2007, 21, 2743-2749.

2006

Men, L. and Wang, Y.* Fragmentation of the deprotonated ions of peptides containing cysteine, cysteine sulfinic acid, cysteine sulfonic acid, aspartic acid, and glutamic acid.  Rapid Commun. Mass Spectrom., 2006, 20, 777-784.

Hong, H.; Cao, H.; Wang, Y. and Wang, Y.* Identification and quantification of a guanine-thymine intrastrand crosslink lesion induced by Cu(II)/H2O2/ascorbate.  Chem. Res. Toxicol., 2006, 19, 614-621.

Zeng, Y. and Wang, Y.* Facile photocyclization chemistry of 5-Phenylthio-2’-deoxyuridine in duplex DNA.  Org. Lett., 2006, 8, 2527-2530.

Zhang, Q. and Wang, Y.* Differentiation of 2’-O- and 3’-O-methylated ribonucleosides by tandem mass spectrometry.  J. Am. Soc. Mass Spectrom., 2006, 17, 1096-1099.

Jiang, X. and Wang, Y.* Phosphorylation of human high mobility group N1 protein by protein kinase CK2.  Biochem. Biophys. Res. Commun., 2006, 345, 1497-1503.

Jiang, X. and Wang, Y.* Acetylation and phosphorylation of high-mobility group A1 proteins in PC-3 human tumor cells.  Biochemistry, 2006, 45, 7194-7201.

Wang, Y. and Wang, Y.* Synthesis and thermodynamic studies of oligodeoxyribonucleotides containing tandem lesions of thymidine glycol and 8-oxo-2’-deoxyguanosine.  Chem. Res. Toxicol., 2006, 19, 837-843.

Cao, H. and Wang, Y.* Collisionally activated dissociation of protonated 2’-deoxycytidine, 2’-deoxyuridine and their oxidatively damaged derivatives.  J. Am. Soc. Mass Spectrom., 2006, 17, 1335-1341.

Gu, C.; Zhang, Q.; Yang, Z.; Wang, Y.; Zou, Y. and Wang, Y.* Recognition and incision of oxidative intrastrand cross-link lesions by UvrABC nuclease.  Biochemistry, 2006, 45, 10739-46.

Zeng, Y. and Wang, Y.* Sequence-dependent formation of intrastrand crosslink products from the UVB irradiation of duplex DNA containing a 5-bromo-2’-deoxyuridine or 5-bromo-2’-deoxycytidine.  Nucleic Acids Res., 2006, 34, 6521-6529.

Sun, W.; Lee, T. S.; Zhu, M.; Gu, C.; Wang, Y., Zhu, Y., and Shyy, J. Y.* Statins activate AMP-activated protein kinase in vitro and in vivo.  Circulation, 2006, 114, 2655-2662.

Gao, Y. and Wang, Y.* Site-selective modifications of arginine residues in human hemoglobin induced by methylglyoxal.  Biochemistry, 2006, 45, 15654-15660.

【联系地址】yinsheng.wang@ucr.edu