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yensh金虫 (文坛精英)
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【国际通缉令——国外分析专业名师征集】
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国际通缉令 【活动目的】 希望大家介绍自己收集到的国外（特别是欧美地区）分析化学专业名师； 方便各位立志出国深造的朋友们予以参考！ 【活动方式】 跟帖参加活动 (请提供准确信息，若不清楚请留空) 【奖励方式】 视信息量给予3-10个金币奖励 (信息获取较为困难，提高奖励数，绝无崇外之意！) 【特别鸣谢】谢谢虫友littlewing2007提议！ 特别提醒：此贴是国外分析导师信息贴！ [ Last edited by yensh on 2008-1-5 at 21:32 ] |
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wingcat(金币+10,VIP+0):谢谢提供信息，与楼上信息一并奖励~~~
wingcat(金币+10,VIP+0):谢谢提供信息，与楼上信息一并奖励~~~
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【导师姓名】G. W. Whitesides 【研究方向】此人属于超级大牛，涉足领域极广，与分析相关的方向是Microfluidics 【所在单位】Harvard 【研究成果】 Microfluidics The Whitesides Group is very active in microfluidics. Our previous accomplishments in the field include work on laminar flow in microchannels (Figures 1,2), fabrication of three-dimensional channel topologies (Figures 3) and mixing by chaotic advection (Figure 4). We have also applied microfluidics to fabricate monodisperse polymer, hydrogel, and metal microparticles coated with thin, nylon-coated membranes (Figure 5). Currently, we are working on several projects related to microfluidics, including exploiting the behavior of bubbles and droplets for mixing and other applications, manipulating samples electrokinetically and probing the use of solder as electrodes in microchannels. Bubbles and Droplets in Microchannels Our recent experiments in microfluidics include investigations into the behavior of bubbles and droplets in microchannels. Specifically, we are interested in four sub-areas: (1) enhanced mixing in microfluidic systems using bubbles; (2) the paths from monodisperse to chaotic bubbling in flow-focusing devices; (3) the production of bubbles with uniquely high periodicities in modified flow-focusing systems; (4) the path-selection process that bubbles demonstrate as they move through a network. Mixing in microchannels, in particular, is an important challenge in the microfluidics subgroup of our laboratory (the other areas introduced here are described further in the complexity section of the website). Mixing between streams of fluid that flow in a laminar fashion is difficult to achieve. Previously, we have introduced a method to enhance mixing involving multiple lithographic steps. Our current work uses bubbles to facilitate the folding over of streams of fluid as they proceed through a network of microchannels (Movie 6). The bubbles partially block the channels in which they move, causing a portion of a stream of bulk fluid to cross over into the channel in which the other stream moves. This process is repeated several times before the streams are mixed fully, with the final mixing device occupying an area of only a square millimeter on the chip. Electrokinetic Flow in Microfluidic Channels We are exploring electrokinetically-driven microfluidic systems for separation of complex biological samples. Our ultimate goal is to provide a new sample handling method (femtomole/nL) for proteomic analysis and high-throughput biochemical assays. Currently, we are investigating geometrical designs, surface coatings and concentration techniques such as isotachophoresis. TWIST Valves We have developed a new approach for controlling the flow of fluids in microfluidic channels. TWIST valves consist of small machine screws (500 um diameter) embedded in a layer of polyurethane cast above microfluidic channels fabricated in poly(dimethylsiloxane) (PDMS). The polyurethane is cured photochemically with the screws in place; on curing, it bonds to the surrounding layer of PDMS and forms a stiff layer that retains an impression of the threads of the screws (Figure 7). The valves are separated from the ceiling of microfluidic channels by a layer of PDMS, and are integrated into channels using a simple procedure compatible with rapid prototyping. Turning the screws actuates the valves by collapsing the PDMS layer between the valve and channel, controlling the flow of fluids in the underlying channels. These valves have the useful characteristic that they do not require power to retain their setting (on/off). They also allow settings between "on" and "off", resist large back pressures (>350 kPa) without failure, and can be integrated into portable, disposable microfluidic devices for carrying out biological assays (Figure 8). TWIST Pumps We have designed a system for storing and pumping fluids in microfluidic devices fabricated in poly(dimethylsiloxane) (PDMS) using TWIST valves. The method uses valves to isolate microfluidic reservoirs that are filled with solutions of reagents under pressure; the fluid is released, and the flow rate controlled, by opening one of the valves. Figure 9 shows a microfluidic pump fabricated using this approach. References 1. Jeon, N. L. et al. "Generation of Solution and Surface Gradients Using Microfluidic Systems", Langmuir, 2000, 16, 8311-8316. 2. Wu, H. et al. "Fabrication of Topologically Complex Three-Dimensional Microstructures: Metallic Microknots" J. Am. Chem. Soc., 2001, 122, 12691-12699. 3. Stroock, A. D. et al. "Chaotic Mixer for Microchannels" Science, 2002, 295, 647-654. 4. Xu, S. et al "Generation of Monodisperse Particles by Using Microfluidics: Control over Size, Shape, and Composition" Angewandte Chemie 44 (5), 2005, 724-728. 5. Weibel, D. B. et al. "Torque-Actuated Valves for Microfluidics" Analytical Chemistry 77(15); 4726-4733, 2005. 【联系地址】gwwhitesides@gmwgroup.harvard.edu http://gmwgroup.harvard.edu/ http://gmwgroup.harvard.edu/contact.html |
36楼2008-01-24 19:12:06
lovehappy2008
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2楼2007-12-29 18:19:15
liu2004m
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yensh(金币+5,VIP+0):谢谢参与！
yensh(金币+5,VIP+0):谢谢参与！
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沙发,哈哈 来一个 【导师姓名】杨培东 【研究方向】纳米材料 【所在单位】加州大学伯克利分校化学系 【研究成果】大家都知道的 【联系地址】p_yang@berkeley.edu |
3楼2007-12-29 18:22:41
shanzhaohui
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4楼2007-12-29 19:54:24
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