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yensh

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Jacqueline K. Barton

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yensh(金币+6,VIP+0):谢谢提供信息

【导师姓名】Jacqueline K. Barton
Arthur and Marian Hanisch Memorial Professor of Chemistry at the California Institute of Technology
【研究方向】DNA biosensors, DNA-Mediated Electron Transfer, DNA Recognition and Reactions by Metallointercalators
【所在单位】Department of Chemistry, CalTech
【研究成果】

1.  Electron transfer between bases in double helical DNA
SCIENCE 283 (5400): 375-381 JAN 15 1999
2.  Oxidative thymine dimer repair in the DNA helix
SCIENCE 275 (5305): 1465-1468 MAR 7 1997
3.  Rates of DNA-mediated electron transfer between metallointercalators
SCIENCE 273 (5274): 475-480 JUL 26 1996
4.  LONG-RANGE PHOTOINDUCED ELECTRON-TRANSFER THROUGH A DNA HELIX
SCIENCE 262 (5136): 1025-1029 NOV 12 1993
5.  Oxidative DNA damage through long-range electron transfer
NATURE 382 (6593): 731-735 AUG 22 1996

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY >50
【简介】
Jacqueline K. Barton is in the Committee on Challenges for the Chemical Sciences in the 21st Century of the book, Beyond the Molecular Frontier: Challenges for Chemistry and Chemical Engineering (2003).

Barton was awarded the Bachelor of Arts degree summa cum laude at Barnard College in 1974 and went on to receive a Ph.D. in Inorganic Chemistry at Columbia University in 1979 in the laboratory of S. J. Lippard. After a postdoctoral fellowship at Bell Laboratories and Yale University in the laboratory of R. G. Shulman, she became an assistant professor of Chemistry and Biochemistry at Hunter College, City University of New York. In 1983, she returned to Columbia University, becoming an associate professor of chemistry and biological sciences in 1985 and professor in 1986. In the fall of 1989, she joined the faculty at Caltech.

Professor Barton has pioneered the application of transition metal complexes as tools to probe recognition and reactions of double helical DNA. Using chiral coordination complexes, matching their shapes, symmetries, and functionalities to sites along the strand, she has designed octahedral metal complexes which recognize nucleic acid sites with affinities and specificities rivaling DNA-binding proteins. These synthetic transition metal complexes have been useful in elucidating fundamental chemical principles which govern the recognition of nucleic acids, in developing luminescent and photochemical reagents as new diagnostic tools, and in laying a foundation for the design of novel chemotherapeutics and biosensors. With these transition metal probes, she has also carried out seminal studies to elucidate electron transfer chemistry mediated by the DNA double helix. This work provides a completely new approach to the study of DNA structure and dynamics and may be critical to understandin g the chemical consequences of radical damage to DNA within the cell.

Barton has received numerous awards. These include the Alan T. Waterman Award of the National Science Foundation (1985), awarded to the outstanding young scientist in the United States, and the American Chemical Society (ACS) Award in Pure Chemistry (1988). She has also received the ACS Eli Lilly Award in Biological Chemistry (1987), the ACS Baekeland Medal (1991), the Fresenius Award (1986), the ACS Garvan Medal (1992), the ACS Tolman Medal (1994), the Mayor of New York's Award in Science and Technology (1988), the Havinga Medal (1995), the Paul Karrer Medal (1996), and the ACS Nichols Medal (1997). She was a fellow of the Sloan Foundation, a Dreyfus Teacher-Scholar, and an NSF Presidential Young Investigator. She is a recipient of a prestigious MacArthur Foundation Fellowship (1991) and she has been elected a member of the American Academy of Arts and Sciences (1991), the American Philosophical Society (1999), and the National Academy of Sciences (2002). She has received honorary do ctorates of science from Knox College (1991), Williams College (1992), New Jersey Institute of Technology (1993), Kenyon College (1994), Lawrence University (1994), and Skidmore College (1997), as well as university medals from Barnard College (1990) and Columbia University (1992). She has, in addition, served the chemical community through her participation in a wide range of governmental and industrial boards and advisory committees.
【联系地址】
jkbarton@caltech.edu

http://www.its.caltech.edu/~jkbgrp/
【其它】
http://www.dow.com/corpgov/leader/barton.htm

http://biochemater.bokee.com/1053070.html