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prog. polym. sci.上online的一篇关于荧光纳米生物成像探针的综述，喜欢的拿走
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来自北京化工大学材料科学与工程学院的尹梅贞教授课题组发表了题为“Design and development of fluorescent nanostructures for bioimaging”的综述，该综述发表在国际顶级综述期刊Progress in Polymer Science杂志上（IF=26.38）。 荧光技术是一种具备了灵敏性、特异性、便利性、多样性等特点的新兴科技，上述特点使其在生物成像方面具有十分广泛的应用。同时，纳米材料具有尺寸小的特征，而由此产生的纳米效应使得材料自身在光学、热学等物理性能方面都有显著的提高。由以上两种技术结合的荧光生物成像纳米探针倍受到科研工作者的关注，并被广泛应用于生命科学等诸多领域，具有重要的学术价值以及广阔的应用开发前景。 这篇综述从荧光纳米结构的组成角度出发，将其分为有机，无机和有机/无机杂化三大类，全面归纳阐述了近年来国内外报道的各种类型荧光纳米结构在生物成像方面的应用。同时简单讨论了各种荧光探针纳米结构的发光机理以及应用设计思路。将荧光纳米技术与生命科学有机结合不但充分体现了学科交叉的重要意义，还使得人们在纳米尺度甚至单分子水平上获取生命过程生物化学信息，可以对单细胞进行原位、实时、动态分析以及定向捕获和分离等等。 文章的通讯作者是北京化工大学的高层次引进人才尹梅贞教授，第一作者为尹梅贞教授课题组的博士研究生陈梦君。该综述得到了国家自然科学基金，教育部新世纪优秀人才支持计划等基金资助。 送审过程中，审稿人也给予了很高评价： Referee 1: Good review on an interesting field that is a hot topic. As a review this is a valuable paper. Referee 2: Although there are now many reviews on this topic, this is the first to incorporate, classify and compare nearly all of the fluorescent nanostructures to date. As such the review offers reader a comprehensive, one-stop review showing the complete toolset for bioimaging. 该篇Progress in Polymer Science综述目前为online状态，其DOI为http://dx.doi.org/10.1016/j.progpolymsci.2013.11.001 综述的摘要如下： Because fluorescence-based techniques are inherently sensitive, selective, convenient, diverse, non-destructive, potentially real time and in situ, they have been widely used in biological imaging. Especially those, with specific fluorescent nanostructures (FNSs) as detecting media in bioimaging, have already been intensively studied for more than a decade because of the convenient transduction of optical signal, high sensitivity and rapid response of FNSs. In this review, we summarize the major strategies to design FNSs with specific structures for biological imaging. First, recent advances are briefly introduced. Then, the specific design of FNSs and their applications are reviewed, in which their fluorescence mechanism, strategies in designing and development, preparation methods, and some representative applications in bioimaging are described. Finally, future perspectives and ongoing issues of FNSs and their applications in bioimaging are discussed. Although many FNSs have been synthesized and applied biologically, many studies still should be done before they can be widely employed as fluorescent probes in clinical tests. With further advances in design and synthesis of high quality multifunctional FNSs, the widespread application of FNSs may be expected not only in advanced bioimaging, but also in ultra-sensitive molecular diagnosis, novel light-emitting nanodevices and intracellular drug delivery. |
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