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[Science]铁基催化：铁基催化剂用于酮及亚胺类化合物非对称加氢 已有1人参与
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Title: Amine(imine)diphosphine Iron Catalysts for Asymmetric Transfer Hydrogenation of Ketones and Imines Weiwei Zuo, Alan J. Lough, Young Feng Li, Robert H. Morris* Abstract: A rational approach is needed to design hydrogenation catalysts that make use of Earth-abundant elements to replace the rare elements such as ruthenium, rhodium, and palladium that are traditionally used. Here, we validate a prior mechanistic hypothesis that partially saturated amine(imine)diphosphine ligands (P-NH-N-P) activate iron to catalyze the asymmetric reduction of the polar bonds of ketones and imines to valuable enantiopure alcohols and amines, with isopropanol as the hydrogen donor, at turnover frequencies as high as 200 per second at 28°C. We present a direct synthetic approach to enantiopure ligands of this type that takes advantage of the iron(lI) ion as a template. The catalytic mechanism is elucidated by the spectroscopic detection of iron hydride and amide intermediates. ![[Science]铁基催化：铁基催化剂用于酮及亚胺类化合物非对称加氢](https://muchongimg.xmcimg.com/data/bcs/2013/1129/w167h832300_1385694054_430.jpg#opennewwindow) 1080.jpg link: www.sciencemag.org/content/342/6162/1080[ Last edited by leiws on 2013-11-29 at 11:15 ] |
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2013-11-29 11:01:55, 533.19 K
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