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leiws

至尊木虫 (职业作家)

木虫浪子

应助: 327 (大学生)
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在线: 2143.1小时
虫号: 832300
注册: 2009-08-22
性别: GG
专业: 催化化学

[交流] [Science]铁基催化：铁基催化剂用于酮及亚胺类化合物非对称加氢已有1人参与

Title: Amine(imine)diphosphine Iron Catalysts for Asymmetric Transfer Hydrogenation of Ketones and Imines
Weiwei Zuo, Alan J. Lough, Young Feng Li, Robert H. Morris*
Abstract:
A rational approach is needed to design hydrogenation catalysts that make use of Earth-abundant
elements to replace the rare elements such as ruthenium, rhodium, and palladium that are traditionally
used. Here, we validate a prior mechanistic hypothesis that partially saturated amine(imine)diphosphine
ligands (P-NH-N-P) activate iron to catalyze the asymmetric reduction of the polar bonds of ketones
and imines to valuable enantiopure alcohols and amines, with isopropanol as the hydrogen donor, at
turnover frequencies as high as 200 per second at 28°C. We present a direct synthetic approach to
enantiopure ligands of this type that takes advantage of the iron(lI) ion as a template. The catalytic
mechanism is elucidated by the spectroscopic detection of iron hydride and amide intermediates.

1080.jpg
link: www.sciencemag.org/content/342/6162/1080[ Last edited by leiws on 2013-11-29 at 11:15 ]

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