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leiws

至尊木虫 (职业作家)

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专业: 催化化学

[交流] [Science]钴基催化：高通量法筛选非对称加氢催化剂

Title:Cobalt Precursors for High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation Catalysts
Max R. Friedfeld,1 Michael Shevlin,2 Jordan M. Hoyt,1 Shane W. Krska,2 Matthew T. Tudge,2 Paul J. Chirik1
Abstract：
Asymmetric hydrogenation of alkenes is one of the most widely used methods for the preparation of single
enantiomer compounds, especially in the pharmaceutical and agrochemical industries. For more than
four decades, precious metal complexes containing rhodium, iridium, and ruthenium have been
predominantly used as catalysts. Here, we report rapid evaluation of libraries of chiral phosphine ligands
with a set of simple cobalt precursors. From these studies, base metal precatalysts have been discovered
for the hydrogenation of functionalized and unfunctionalized olefins with high enantiomeric excesses,
demonstrating the potential utility of more earth-abundant metals in asymmetric hydrogenation.

link:http://www.sciencemag.org/content/342/6162/1076[ Last edited by leiws on 2013-11-29 at 11:06 ]

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附件 1 : 1076.full.pdf

2013-11-29 10:44:10, 788.08 K

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