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Tumor Targeting in Cancer Therapy
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Tumor Targeting in Cancer Therapy By Michel Pagé -------------------------------------------------------------------------------- Publisher: Humana Press Number Of Pages: 466 Publication Date: 2002-04-01 ISBN-10 / ASIN: 0896039196 ISBN-13 / EAN: 9780896039193 Binding: Hardcover -------------------------------------------------------------------------------- Book Description: In Tumor Targeting in Cancer Therapy, Dr. Michel Pagé and a panel of authoritative experts from the drug industry, clinics, and academia introduce the principles and techniques of tumor targeting and critically survey their applications from laboratory to bedside. By concisely synthesizing the many technical details, the authors illuminate this innovative technique, ranging from the fundamentals of drug targeting and in vivo and in vitro experimentation, to such emerging therapeutic uses as radioimmunotherapy, radioimmunodetection, therapy with cytotoxic antibodies, immunotoxins, enzyme prodrug immunotherapy, and immunotherapeutics with fusion proteins. There are also reviews of targeting tumors with radioimmunoconjugates, photodynamic therapy, and magnetic drugs, as well as discussions of the internalization of antibodies, bioconjugation and biodistribution, the use of cytotoxic drugs, and the pros and cons of targeting by antibody or ligand. PART I. A REVIEW 1 The Current Status of Tumor Targeting: A Review.......................... 3 Tarunendu Ghose 2 Clinical Applications of Targeted Therapeutics ............................ 79 Tarunendu Ghose PART II. TARGETING TUMORS WITH DRUG ANTIBODY CONJUGATES 3 Targeting the CD22 Receptor with RNA Damaging Agents ...... 109 Huaitian Liu, Dianne L. Newton, Hans J. Hansen, Stanislaw M. Mikulski, David M. Goldenberg, Edward A. Sausville, and Susanna M. Rybak 4 The Development of Liposomes for Enhanced Delivery of Chemotherapeutics to Tumors ............................................. 119 Paul Tardi, Ludger Ickenstein, Marcel Bally, and Lawrence Mayer 5 Overcoming Multiple Drug Resistance with Anti-Pgp Carrier ............................................................... 137 Brigitte Pagé and Michel Pagé 6 Targeting with Transferrin ............................................................ 151 Mandip Singh 7 Synthesis and Evaluation of Paclitaxel Immunoconjugate with Antitumor Activity In Vitro ............................................. 165 Jairo Jaime Correa and Michel Pagé 8 The Use of Drug-Monoclonal Antibody Conjugates for the Treatment of Cancer ................................................................. 179 Geoffrey A. Pietersz and Ian F. C. McKenzie PART III. TARGETING TUMORS WITH ANTIBODIES 9 Targeting Vascular Endothelium with Antibodies....................... 199 Przemek Twardowski and Kim Margolin 10 Targeting B-Cell Non-Hodgkin’s Lymphoma with Monoclonal Antibodies .................................................... 211 Christian Buske and W. Hiddemann 11 From Bench to Bedside: Development of Rituximab (Rituxan ®  , A Monoclonal Antibody for the Therapyof Non-Hodgkin’s Lymphoma .................................................. 225 Roland Newman 12 Mylotarg: The First Antibody-Targeted Chemotherapy Agent ...239 Philip R. Hamann and Mark S. Berger PART IV. TARGETING TUMORS WITH RADIOIMMUNOCONJUGATES 13 188Rhenium-Labeled Trisuccin-ΔCH2HUCC49 as a Radioimmunotherapy Model in Nude Mice ..................... 257 Ahmad Safavy and Donald J. Buchsbaum PART V. TARGETING TUMORS WITH IMMUNOTOXINS 14 General Approach for Targeting Toxins ...................................... 279 Manish Monga, Richard A. Messmann, and Edward A. Sausville 15 Antibody-Toxin Conjugates: Chemistry of Coupling and Purification ........................................................................289 Silvana Canevari, Maria Ines Colnaghi, Luigi Cattel, and Franco Dosio 16 Shiga-Like Toxins as Targeted Anticancer Agents ..................... 307 Paul LaPointe and Jean Gariépy PART VI. TARGETING TUMORS WITH ANTIBODY-ENZYME CONJUGATES (ADEPT) 17 Antibody-Directed Enzyme Prodrug Therapy with Carboxypeptidase G2: Clinical Studies ........................... 321 Kenneth D. Bagshawe PART VII. PHOTODYNAMIC THERAPY 18 Photodynamic Therapy: Targeting Cancer Cells with Photosensitizer-Bioconjugates ......................................... 329 Cynthia M. Allen, Wesley M. Sharman, and Johan E. van Lier 19 Tumor Targeting Using PEG-m-THPC for Photodynamic Therapy in a Rat Ovarian-Cancer Model ................................. 363 René Hornung PART VIII. TARGETING TUMORS WITH MAGNETIC DRUGS 20 Targeting Tumors with Magnetic Drugs ..................................... 379 Andreas S. Lübbe, Christian Bergemann, and Christoph Alexiou PART IX. PRINCIPLES AND TECHNIQUES IN TARGETING 21 Internalization of Antibodies ........................................................ 391 Jairo Jaime Correa 22 Bioconjugation and Biodistribution ............................................. 411 Francesco M. Veronese and Paulo Caliceti 23 Principles of Antitumor Targeting of Cytotoxic Drugs ............... 431 Gene M. Dubowchik 24 Targeting by Antibody or Ligand: Which Is Better? ................... 449 Douglas A. Lappi Index ........................................................................................................................... 459 http://rapidshare.com/files/76709180/ASD_Tumor_Targeting_in_Cancer_Therapy.rar |
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