| 查看: 3996 | 回复: 68 | |||||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||||
[交流]
【2013-12-31】Frontiers in Microbiology专刊征稿【SCIE】
|
|||||
DNA Replication Origins in Microbial Genomes 导师主持的专刊，如有合适的工作，欢迎各位投稿。如有兴趣，可站内信联系。 http://www.frontiersin.org/evolu ... origins_in_mic/2193 In collaboration with Frontiers in Microbiology, we are organizing a Research Topic titled "DNA Replication Origins in Microbial Genomes”. Frontiers, a Swiss open-access publisher, recently partnered with Nature Publishing Group to expand its researcher-driven Open Science platform. Frontiers articles are rigorously peer-reviewed, can be disseminated freely and are widely read by your colleagues and by the broader scientific and medical research communities. Research Topic DNA replication, a central event for cell proliferation, is the basis of biological inheritance. Complete and accurate DNA replication is integral to the maintenance of the genetic integrity of organisms. In all three domains of life, DNA replication begins at replication origins. In bacteria, replication initiates from a single replication origin (oriC), which contains several DnaA boxes. In eukaryotic genomes, replication initiates from significantly more replication origins, ranging from hundreds in yeast to tens of thousands in human, activated simultaneously at a specific time. For eukaryotic organisms, replication origins are best characterized in the unicellular eukaryote budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe. The budding yeast origins contain an essential sequence element called the ARS (autonomously replicating sequence), while the fission yeast origins consist of AT-rich sequences. Within the archaeal domain, the multiple replication origins have been identified by a predict-and-verify approach in the hyperthermophilic archaeon Sulfolobus. Archaeal origins contain two or more short repetitive DNA sequences, known as origin recognition boxes (ORBs). It appears that archaea have a simplified version of the eukaryotic replication apparatus, which has led to considerable interest in the archaeal machinery as a model of that in eukaryotes. The identification of replication origins is important not only in providing insights into the structure and function of the replication origins but also in understanding the regulatory mechanisms of the initiation step in DNA replication. Therefore, intensive studies have been carried out on the identification of replication origins in the last two decades. The pioneer work to identify bacterial oriCs in silico is the GC-skew analysis. Later, a method of cumulative GC skew without sliding windows was proposed to give better resolution. Meanwhile, an oligomer-skew method was also proposed to predict oriC regions in bacterial genomes. As a unique representation of a DNA sequence, the Z-curve method has been proved to be an accurate and effective approach to predict bacterial and archaeal replication origins. Budding yeast origins have been predicted by Oriscan using similarity to the characterized ones, while the fission yeast origins have been indentified initially from AT content calculation. In comparison with the in silico analysis, the experimental methods are convincing and reliable, but time-consuming and labor-intensive. The microbial replication origins can be identified by several experimental methods including construction of replicative oriC plasmids, microarray-based or high-throughput sequencing-based marker frequency analysis, two-dimensional gel electrophoresis analysis and replication initiation point mapping (RIP mapping) etc. The recent genome-wide approaches to identify and characterize replication origin locations have boosted the number of mapped yeast replication origins. The availability of increasing complete microbial genomes and emerging approaches has created challenges and opportunities for identification of their replication origins in silico, as well as in vivo. This research topic invites for the studies of microbial replication origins, addressing all the issues mentioned above, by in silico analyses as well as in vivo experiments. Manuscripts describing original research, methods, opinions, reviews are all welcome, which would provide a comprehensive overview of this field. [ Last edited by 流风易逝 on 2013-11-4 at 12:03 ] |
回复此楼» 猜你喜欢
308求调剂
已经有3人回复
-
321求调剂
已经有11人回复
-
一志愿中海洋材料工程专硕330分求调剂
已经有8人回复
-
330求调剂
已经有4人回复
-
304求调剂
已经有7人回复
-
一志愿南京理工大学085701资源与环境302分求调剂
已经有6人回复
-
南京大学化学376求调剂
已经有3人回复
-
考研调剂求学校推荐
已经有5人回复
-
323求调剂
已经有3人回复
-
317求调剂
已经有12人回复
» 抢金币啦！回帖就可以得到:
-
持续创业者，A8离异男征婚，事业遇到瓶颈，寻找创业生活伴侣
+1/462
-
福建师范大学叶应祥课题组招收2026级博士研究生
+2/160
-
浙江大学侯阳教授团队诚聘博士后---高性能固态电解质与固态电池器件设计
+1/86
-
济南大学林秀娟教授招收材料类博士生
+1/85
-
天津理工大学国家杰青王铁课题组招收2026年博士研究生
+1/84
-
招收材料与化学相关专业硕士研究生
+1/84
-
双一流南京医科大学招计算机、AI、统计、生物信息等方向26年9月入学博士
+1/83
-
2026年工科硕士调剂-上海大学全国重点实验室团队-材料数据挖掘方向-研究生3-5人
+1/30
-
2026年黄河科技学院纳米功能材料研究所招聘
+2/26
-
中山大学院士团队微纳器件、脑机接口方向博士招生、博后招聘
+1/18
-
---大龄的未婚男找结婚女对象
+1/17
-
湖南大学微生物结构与功能实验室2026年计划招收博士研究生
+1/16
-
江西赣州-赣南师范大学-学校推荐
+1/8
-
211/双一流---石河子大学---有机化学方向招调剂生
+1/7
-
福州大学国家级人才汤育欣教授课题组2026年招收”申请考核制“储能电池方向博士研究生
+1/6
-
【武汉高校】【新能源材料与器件课题组】 招收优秀硕士调剂生！！！
+5/5
-
东北林业大学（211，双一流）宋老师课题组招收高分子、化学、复合材料等方向研究生
+1/3
-
125603工业工程与管理调剂
+1/1
-
【2026年春季补录】厦门大学田中群院士/易骏教授纳米光子学团队招收2026年入学博士生
+1/1
-
博后即将出站，求稳定的教职
+1/1
69楼2015-01-28 16:27:50
