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HD-ZIPIII and ETT/ARF family genes encode transcriptional regulators and are negatively regulated by the small RNAs miR166 and tasiR-ARF, respectively. The SHL/SHO pathway affects the regulation of these genes simultaneously, which suggests that there is a link between miR166-mediated regulation of HD-ZIPIII and tasiR-ARF-mediated regulation of ETT/ARF. One possibility is that HD-ZIPIII and ETT/ARF genes have opposing functions. Whereas HD-ZIPIII genes promote SAM formation and adaxial leaf fates, ETT/ARF genes suppress them,and their corresponding small RNAs regulate the balance between these two factors to maintain the domains marked by the expression of HD-ZIPIII and miR166 in a bistable manner. In this model, defects in ETT/ARF-tasiR-ARF regulation that lead to overaccumulation of ETT/ARF gene products, as in shl/sho mutants, promote the accumulation of miR166 by suppressing SAM formation and adaxial leaf fate. It is also possible that a defect in the production of an unknown ta-siRNA, directed at the precursors of miR166, resulted in increased the stability of the precursors and overaccumulation of miR166. In summary, we demonstrated that a set of RNAi-related components, whose counterparts in Arabidopsis are involved in ta-siRNA production, is required for the initiation of the SAM, a group of stem cells in plants, during rice embryogenesis. Complete loss of ta-siRNA does not affect SAM initiation in Arabidopsis, which suggests that this mechanism of regulation of stem cell establishment does not operate in Arabidopsis (25, 27). Small RNAs are often conserved between species and mediate fundamental developmental processes by regulating the expression of key regulatory molecules in both plants and animals. The establishment of stem cells is fundamental to all plants, and therefore the regulators of this process, such as transcriptional regulators or signaling molecules, are also likely to be conserved. Our analysis of rice shl/sho mutants revealed that miR166- mediated regulation of HD-ZIPIII expression is sensitive to the ta-siRNA production pathway during SAM formation in rice embryogenesis. Thus, the small RNA pathway enables the unique regulation even on the fundamental process in development, the stem cell establishment, in different species. [ Last edited by acnotlove on 2007-12-6 at 20:24 ] |
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2楼2007-12-04 14:02:13
wangchen2004
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3楼2007-12-04 15:46:25
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高清Zipiii和运送需时/东盟地区论坛家族基因编码转录 监管人员与负调节，由小RNAs miR166和tasiR -东盟地区论坛等。该Shl /郑硕通路 影响调节这些基因的同时， 显示出有连接miR166介导的调控 高清zipiii和tasiR -东盟地区论坛介导的调控运送需时/东盟地区论坛。 一种可能性是，高清Zipiii和运送需时/东盟地区论坛基因 反对的职能。而高清Zipiii基因促进萨姆 形成与近轴面叶的命运，运送需时/东盟地区论坛基因镇压，其相应的小RNAs规范之间的平衡 这两个因素，以维持域名，标志着由 表达高清Zipiii和miR166在双稳态的方式。在 这种模式的弊端运送需时/东盟地区论坛- tasiR东盟地区论坛调控导致 以overaccumulation的运送需时/东盟地区论坛基因产物，因为在Shl /郑硕 突变体，促进积累miR166受打压 萨姆的形成与近轴面叶的命运。它也可能会有 缺损，生产一种未知的大安森林小分子干扰核糖核酸，针对 先驱们miR166 ，造成更多的稳定 前体和超过积累的miR166 。 总之，我们证明了一套核糖核酸干扰有关 部件，其对应拟南芥参与 张大千的小分子干扰核糖核酸生产，是需要启动的软件资产管理， 一组干细胞植物，在水稻细胞胚胎发生。 完全丧失安森林小分子干扰核糖核酸并不影响萨姆起爆 拟南芥中，这表明，这一新机制的调节 干细胞的建立，并不在拟南芥（ 25 ， 27 ） 。 小rna往往是保守的物种之间和调停 基本的发展进程中所规范的表达 关键调控分子在双方的植物和动物。该 建立干细胞是基本的所有植物，并 因此，监管机构的这个过程中，如转录 监管机构或信号分子，也可能得到保护。 根据我们的分析，水稻Shl /郑硕突变体显示miR166 - 导的调控高清Zipiii表达的是，敏感地认识到 张大千的小分子干扰核糖核酸的生产途径在山姆形成水稻 胚胎发育。因此，小核糖核酸通路，使 独特的调节，甚至对基本过程的发展， 干细胞的建立，在不同的物种。 |
4楼2007-12-04 16:01:14
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