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cainiaodui新虫 (小有名气)
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An anti-DLL4 antibody, OMP-21M18, was found to have anti-tumor activity in patient-derived xenograft models independent of any effect on angiogenesis . This antibody does not cross-react with murine DLL4 and therefore has no effect on the vasculature in murine xenografts. The combination of blocking DLL4 in tumor and vascular cells was shown to have an additive effect. Importantly, inhibition of DLL4 not only reduced tumor growth but also reduced tumor initiating cells as shown by serial transplantation experiments |
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yili_90
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