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To model DNA, we assume the charge per unit length is ¦Ë, which is about one negative charge per 1.7Åof length. For simplicity,we assume that DNA is a long, charged, cylindrical molecule. The cylinder diameteris about 20 Å. The electrical field of a long strand of DNA in water depends on the perpendicular distance r from the strand and on ¦Ë.The electric field lines must point inward because DNA is negatively charged.Denoting the electric field at a distance r from the cylinder by E(r), we observe that it is inversely proportional to the dielectric constant and inversely proportional to some power, say r¦Á, of r, hence we write: E(r) = const k*¦Ë/¦Å*r¦Á (2.27) In vacuum, the electric field of a monopole of charge Q a distance R away is kQ/R2. Since ¦Ë is a charge per unit length, ¦Á = 1, hence: E(r) = 2 k*¦Ë/¦Å*r (2.28) Since E(r) = −dV/dr, we have an equivalent form of Equation (2.28). dV (r)/dr= −2k*¦Ë/¦Å*r (2.29) Integrating Equation (2.29), we see that: V (r) = −2k*¦Ë*ln r/¦Å + k0 (2.30) In Equation (2.30), k0 is a constant conveniently chosen to be zero. Suppose a positive monovalent ion moves in from a distance of 1¦Ìm to the surface of the DNA. The work done or W will be: W = |e |V (r = 1¦Ìm) − |e|V (r = 10Å (2.31)Hence: W = 10 ¡¤ 2 ¡¤ 10−20J (2.32) Using k = 8.99 ¡Á 109 m2/C2, = 80.4, ¦Ë = −|e| per 1.7 ¡Á 10−10m, and e = 1.6 ¡Á 10−19C from Equation (2.32) ÎÒÏëÇë½ÌÏÂ2¡£27ÖеÄÄǸör¦ÁÊÇʲô°¡£¬Õâ¸öÊÇÈçºÎÔÚÍÆµ¼µÄ£¿ |
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