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zjlizijian新虫 (小有名气)
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[求助]
中译英，有空的帮下忙
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| 恶性肿瘤是危害人类健康和生命的重大疾病，近几十年来，抗肿瘤新药研发已经取得了显著成功。在抗肿瘤药物的研发中，以生物靶分子为基础进行抗肿瘤药物先导化合物的筛选是抗肿瘤药物的研究热点之一。DNA G-四链体结构的发现及现代分子生物学技术对其生理功能的揭示，为目前抗肿瘤药物研发提供了一个新的契机。能够诱导DNA形成G-四链体结构或者与G-四链体特异性结合，并使之稳定的化合物有望抑制肿瘤细胞的生长，从而达到抗癌的作用。因此，以G-四链体为靶点的抗肿瘤药物的研究引起了人们的广泛关注。 |
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yili_90
金虫 (正式写手)
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4楼2013-10-07 13:17:06
hobbit2005
金虫 (小有名气)
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zjlizijian(phu_grassman代发): 金币+7, thanks 2014-01-09 16:39:38
zjlizijian(phu_grassman代发): 金币+7, thanks 2014-01-09 16:39:38
|
Cancer has been considered to be on of the most serious disease threatening health and life of human beings. The development of new anti-cancer drugs has made remarkable progress in recent decades, among which one of the most focused method is the screening of the precursor compound based on the bio-target molecules. The discovery of DNA G-四连体 structure and the reveal of its biological function via modern molecular biological technology have supplied a new opportunity in the development of anti-cancer drugs. The ability of compound that can induce and stablize DNA to form G-四连体 structure or to combine with its specific characterization would finally realize the function of anti-cancer. Thus, the research of the G-四连体 target molecule based anti-cancer drugs have been arousing wide concerns recently. PS. 四连体自己翻译一下吧。 |
2楼2013-10-07 10:29:09
yili_90
金虫 (正式写手)
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真强必胜: 金币+1, 谢谢 2014-01-08 21:41:26
zjlizijian(phu_grassman代发): 金币+8, good job. 2014-01-09 16:39:30
真强必胜: 金币+1, 谢谢 2014-01-08 21:41:26
zjlizijian(phu_grassman代发): 金币+8, good job. 2014-01-09 16:39:30
| Malignant tumor is a major disease which jeopardize health and life. Fortunately, new drug research of antineoplastic has made remarkable progress in recent decades. One of the hotpots in antineoplastic drugs research is to filter lead compounds of antineoplastic drugs via the basis like bio-target molecule. Discovering the structure of DNA G-quadruplex and revealing its physical function via modern molecular biology technique provide a new moment for antineoplastic drugs research. And stable compounds which is obtained by Inducing DNA to form G-quadruplex or bind to G-quadruplex specifically might can inhibit the growth of tumor cells and then play a anti-cancer rule. Thus, the method in which regard G-quadruplex as target has aroused much concern in the field of antineoplastic drugs research. |
3楼2013-10-07 13:15:30