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 ÌâÄ¿£ºStudy on the preparation of repaglinide chitosan microspheres with genipin
 ×÷ÕߣºYue Zhang, Xianxian Shi, Yifeng Yu, Yongxing Song.        
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fulin369

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shixianxian: ½ð±Ò+30, ¡ï¡ï¡ïºÜÓаïÖú 2013-10-07 15:31:57
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4Â¥2013-10-07 09:42:12
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fulin369

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shixianxian: ½ð±Ò+10 2013-10-07 15:32:06
è¾è¾: »ØÌûÖö¥ 2013-10-08 10:32:38
Accession number:       
20132916519659
        Title:        Study on the preparation of genipin crosslinked chitosan microspheres of resveratrol and in vitro release
        Authors:         Zhang, Yue1, 2, 3; Yu, Yi-Feng1, 2, 3 ; Shi, Xian-Xian1; Zhao, Shu-Chun1, 2, 3; Chen, Ai-Bing1, 2; Huang, Dao-Wei1; Niu, Dong-Jie1; Qin, Zhen1
        Author affiliation:        1 School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China
                2 Hebei Research Center of Pharmaceutical and Chemical Engineering, Shijiazhuang 050018, China
                3 State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang 050018, China
        Corresponding author:         Yu, Y.-F. (yifengyu@hebust.edu.cn)
        Source title:        Journal of Polymer Research
        Abbreviated source title:        J Polym Res
        Volume:        20
        Issue:        7
        Issue date:        2013
        Publication year:        2013
        Article number:        175
        Language:        English
        ISSN:         10229760
        CODEN:         JPOREP
        Document type:        Journal article (JA)
        Publisher:        Springer Netherlands, Van Godewijckstraat 30, Dordrecht, 3311 GZ, Netherlands
        Abstract:        Resveratrol has attracted considerable public and scientific attention because of its beneficial effects on human health. In this study, resveratrol was encapsulated into chitosan microspheres for improving the stability and evaluating the ability of controlled release. Chitosan microspheres were prepared by using an emulsification-crosslinking method, and specifically, a natural extraction genipin was used as crosslinking agent for pursuit better physiological compatibility. Factors which influence on the shape and dispersity of microspheres were investigated to optimize the preparing process of resveratrol loaded genipin-chitosanmicrospheres. The optimum condition was obtained and the prepared resveratrol loaded genipin-chitosanmicrospheres were characterized by many technical instruments. Entrapment efficiency of resveratrol in genipin-chitosanmicrospheres is up to 87.6 %, and loading capacity is 7.9 %. The in vitro release rate in pH 3.6 buffer solution reached to 33.8 % within 72 h, but was lower in pH 7.4 buffer solution. © 2013 Springer Science+Business Media Dordrecht.
        Number of references:        44
        Main heading:         Resveratrol
        Controlled terms:         Chitosan  -  Emulsification  -  Microspheres
        Uncontrolled terms:         Beneficial effects  -  Chitosan microspheres  -  Cross linked chitosan  -  Cross linking agents  -  Entrapment efficiency  -  Genipin  -  In-vitro  -  Loading capacities
        Classification code:         802.3 Chemical Operations -  804.1 Organic Compounds -  818 Rubber and Elastomers
        DOI:        10.1007/s10965-013-0175-8
        Database:        Compendex
                Compilation and indexing terms, © 2013 Elsevier Inc.

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5Â¥2013-10-07 09:45:32
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shixianxian: ½ð±Ò+10, ¡ïÓаïÖú 2013-10-07 15:31:45
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2Â¥2013-10-06 11:28:42
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shixianxian

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ÒýÓûØÌû:
5Â¥: Originally posted by fulin369 at 2013-10-07 09:45:32
Accession number:       
20132916519659
        Title:        Study on the preparation of genipin crosslinked chitosan microspheres of resveratrol and in vitro release
        Authors:         Zhang, Yue1, 2, 3; Yu, Yi-Feng1, 2, ...

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6Â¥2013-10-07 15:30:57
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shixianxian

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4Â¥: Originally posted by fulin369 at 2013-10-07 09:42:12
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