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大家帮忙校对一下 谢谢 急啊 Radical reactions have been investigated intensively over the last two decades. The new synthetic methods that have emerged from this work are complementary to ionic processes and are characterized by mild reaction conditions and broad functional-group tolerance. The potential of these reactions is immense, as demonstrated by their recent use in the synthesis of complexnatural products. However, several aspects of this chemistry merit further investigation to increase the synthetic efficiency of the radical approach. Among these objectives, the development of nontoxic and environmentally friendly reagents to perform efficient radical reactions represents a challenging target. The tin hydride mediated alkenyl radical translocation/ cyclization process developed by Curran et al. represents a powerful procedure for the preparation of functionalized fivemembered rings by selective activation of a C H bond. Recently, we reported an efficient tin-free version of this reaction involving thiophenol for the preparation of cyclopentane derivatives through a 1,5-hydrogen transfer/cyclization sequence[Eq.(1); AIBN=azobisisobutyronitrile]. 过去的二十年里，自由基反应已被广泛的研究。 本操作中出现的新的合成方法是离子方法的补充，其特点在于其温和的反应条件和广阔的官能团容忍度。正像它们最近在合成复杂的天然产物的应用一样，此类反应的潜力是巨大的，。然而，此化学方法优点的几个方面促进了提高自由基方法合成效率的研究。在这些目标中，发展无毒、环境友好型试剂实施有效的自由基反应是一具有挑战性的目标。Curran等发明了用氢化锡介导的自由基易位/环化过程是一种通过C H键的选择性氧化制备功能五元环的高效的方法。近来，我们报道了一种通过1，5氢易位/环化序列[方程（ 1 ） ; 偶氮二异丁腈 ]， 涉及苯硫酚而不含锡的制备环戊烷衍生物的反应。 |
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本文的新合成方法是离子方法的补充，其特点在于其温和的反应条件和广阔的官能团容忍度。正像它们最近在合成复杂的天然产物的应用一样，此类反应的潜力是巨大的。虽然过去的二十年里，自由基反应已被广泛的研究，并且利用本化学方法的几个方面优点提高自由基合成效率的合成研究也发展较快，但发展无毒、环境友好型高效的自由基反应这一挑战性的研究刚刚开始。与Curran等发明的用氢化锡介导的自由基易位/环化——一种通过C H键的选择性氧化过程——制备功能五元环的高效的方法相比较，本文介绍了一种不含锡的苯硫酚1，5氢易位/环化（序列[方程（ 1 ） ; 偶氮二异丁腈] ）制备环戊烷衍生物的反应。 This new synthetic method ,a complementary method to ionic processes in this paper, is possessed of mild reaction conditions and broad functional-group tolerance,and demonstrates its versatility in recent application in synthesis of natural complexity. Though radical reaction has been investigated extensively over the last two decades, and further investigation to improve synthetic efficiency of this radical approach that takes advantage of several aspects of this current synthetic methods has been advancing quite rapidly, it is just recently begining to develop the challenging research work——the high efficiect radical reaction method of nontoxic and environmental friendly reagents. Whereas the tin hydride is used, for preparing functional fivemembered rings ,to induced alkenyl radical translocation/ cyclization process ——oxidaton process by selective activation of a C H bond——developed by Curran et al., thiophenol, non-tin chemical, is used in this new synthetic method for preparing cyclopentane derivatives through a 1,5-hydrogen transfer/cyclization sequence[Eq.(1); AIBN=azobisisobutyronitrile]. |
3楼2007-11-28 10:37:21
yunshenglmm
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2楼2007-11-28 08:37:09
