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wying09铜虫 (正式写手)
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求这段的翻译，谢谢 In recent years, the guidelines of the American Diabetes Association1 and the Association of American Clinical Endocrinologists2 have reached a consensus on the comprehensive management of patients with diabetes mellitus (DM), especially with regard to glycemic control. The Steno-2 study3–5 found that intensive multifactorial interventions could significantly reduce the rates of cardiovascular mortality (43%) and cardiovascular events (41%) in patients with DM, but the success rates for other clinical targets differed markedly. Successful blood pressure and blood lipid reduction rates were high, as indicated by decreased total cholesterol levels in 75% of patients, triglyceride levels in 60%, diastolic pressure in 75%, and systolic blood pressure in 50%, but the reduction of hemoglobin A1c (HbA1c) was less successful (20% of patients achieved the target of 6.5%), indicating that glucose control remains a key challenge in diabetes treatment. The United Kingdom Prospective Diabetes Study6–11 confirmed that HbA1c levels were reduced by 1% in patients with newly diagnosed type 2 DM (T2DM) after intensive intervention; diabetes-related mortality decreased by 21%, and rates of related complications decreased significantly (myocardial infarction by 14%, stroke by 12%, and heart failure by 16%); rates of pathological capillary changes were decreased by 37% and cataract extractions by 19%, and the incidence and mortality rates of peripheral vascular disease were decreased by 43%. Thus, although effective control of HbA1c levels in patients with DM may reduce the incidence of these complications, this target has proved difficult to achieve. |
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lanshenhai
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2楼2013-09-25 09:25:23
friendofyou
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3楼2013-09-26 16:09:29
【答案】应助回帖
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wying09: 金币+5, 翻译EPI+1, ★★★很有帮助 2013-09-28 08:41:04
wying09: 金币+5, 翻译EPI+1, ★★★很有帮助 2013-09-28 08:41:04
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近年来，在美国糖尿病协会1和协会美国临床Endocrinologists2的指导方针已经达成共识的综合管理与糖尿病（ DM ）患者，尤其是血糖控制方面.速记 - 2研究3 -5发现，密集的多因素干预可以显着降低心血管疾病的死亡率率（43％）和DM患者的心血管事件（41％ ） ，但其他临床指标的成功率有显显著差异。成功的血压和血脂降低率是高的，所指示的减少在75％的患者，在60 ％的甘油三酸酯水平，在75 ％的舒张压和收缩压在50％的总胆固醇水平，但降低血红蛋白A1c糖化血红蛋白（HbA1c ）是不太成功的（ 20 ％的患者达到6.5％的目标） ，表明血糖控制在糖尿病治疗中仍然是主要挑战 英国前瞻性糖尿病研究6 -11证实，糖化血红蛋白水平降低1％后，在新诊断的2型糖尿病（ T2DM ）患者密集的干预，糖尿病相关的死亡率下降了21％ ，相关的并发症率下降显着（心肌梗死14％， 12％，中风和心脏衰竭的16％） ;病理毛细血管变化率下降了37％和白内障手术的19％ ，周围血管疾病的发病率和死亡率分别下降了43％ 。因此，虽然有效地控制糖尿病患者的HbA1c水平可能降低这些并发症的发病率，已经证明这个目标很难实现。 (仅供参考) |
4楼2013-09-26 20:34:13
