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[求助]
求翻译转基因小鼠的一段问题
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感激不尽！ Transgenic mice with selective deletion of HIF-1α in SMCs were created by crossbreeding SM22α-promoter–driven Cre mice expressing the Cre reporter ROSA26 (R26R; kindly provided by Marlene Rabinovitch, MD, Stanford University)7 with HIF-1αflox/ flox mice (JAX 007561, B6.129-Hif1αtm3Rsjo/J; Jackson Laboratories). HIF-1α homozygous floxed mice contain the HIF-1α exon 2 flanked by LoxP sites. The Institutional Animal Care and Use Committee at Stanford University approved all the procedures and protocols governing the care and use of laboratory animals. Right ventricular systolic pressure (RVSP) was measured after exposure to either acute or chronic hypoxia. Histological analysis was performed on lung tissue. |
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