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Intriguingly, the investigators show that the differential ability of Jagged1 and Dll4 ligands to activate Notch is dependent on the glycosyltransferase Fringe. Whereas the glycosylated Notch receptor shows strong activation by Dll4 and competitive inhibition by Jagged1, the unglycosylated receptor in the absence of Fringe can be activated by Jagged1 |
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2Â¥2013-09-16 01:24:14
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3Â¥2013-09-16 08:11:56














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