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| In vitro studies confirmed that Jagged1 antagonizes Dll4¨C Notch signaling, suggesting, together with the complementary distribution of Dll4 and Jagged in the growing vascular plexus, that Jagged1 enhances differential Notch activity by competitively interfering with the ability of Dll4 expressed by stalk cells to activate Notch in tip cells |
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- ×¢²á: 2011-08-20
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