| 查看: 145 | 回复: 2 | |||
| 当前主题已经存档。 | |||
zhangwei_suda铁杆木虫 (正式写手)
|
[交流]
Finding the right blend by Non-invasive infra-red spectrometry
|
||
|
Finding the right blend by Non-invasive infra-red spectrometry 20 November 2007 Non-invasive infra-red spectrometry can provide scientists with improved quality checks for pharmaceutical production Enormous efforts in the pharmaceutical industry are currently being made to improve the efficiency of manufacturing procedures, aiming to ensure smooth, high-quality and continuous processes. With this in mind, scientists at the University of Strathclyde, Glasgow, UK, have recently developed a method for looking at how powders blend together during the process itself. Up until now, most methods of looking at powder mixtures required the blending process to be stopped. David Littlejohn and colleagues have now developed a non-invasive NIR (near infra-red) spectrometry method that enables this monitoring to be done in real time. Information on the sample can be collected by measuring the NIR spectra through a window in the reaction vessel, or via a probe in the powder mixture. The movement of particles has an influence on the NIR spectra measured and in the past, scan times have been too long to study the sample accurately. Littlejohn's method has a short scan time and not only examines the dynamics of powder blending, but can also provide quantitative information about the ingredients, all while the sample moves. "Littlejohn's method not only examines the dynamics of powder blending, but also provides quantitative information about the ingredients, all while the sample moves" The method also monitors any possible changes in particle size. This point may prove to be very important for future industrial use, as on this scale, particle cohesion effects have more effect on the blending and time taken for a mixture to reach homogeneity. Littlejohn said that the key advantage of this technique is being able to provide a combination of these different types of information. 'This method will add to the toolbox of techniques that are available, to build further quality checks into a production process,' he said. The team are optimistic that the monitoring method will be successful when used on a larger scale process. 'The methodology described has been applied successfully to a ribbon blender at industrial plant scale, indicating the transferability of the procedure,' said Littlejohn. His team are currently looking at alternative methods of monitoring the blending process, including Raman spectroscopy and acoustic techniques. May Copsey Link to journal article Real-time monitoring of powder mixing in a convective blender using non-invasive reflectance NIR spectrometry Luke J. Bellamy, Alison Nordon and David Littlejohn, Analyst, 2008 DOI: 10.1039/b713919e Source: Chemistry World. |
回复此楼» 猜你喜欢
[武汉纺织大学]材料学院[姜伟团队名称]课题组-2026年硕士研究生调剂信息
已经有0人回复
-
武汉纺织大学-材料科学与工程学院-姜伟杰青团队-招调剂
已经有0人回复
-
有机高分子材料论文润色/翻译怎么收费?
已经有221人回复
-
生物医学材料前沿科普：低密度、高孔隙率的“多孔微球”核心技术与应用全景
已经有1人回复
-
湖南工业大学周贵寅组招生物医学工程（学硕07、08都行）、生物与医药（专硕08）硕士生
已经有0人回复
-
湖南工业大学周贵寅组招生物医学工程（学硕07、08都行）和生物与医药（专硕08）硕士生
已经有0人回复
-
考研求调剂
已经有0人回复
-
2026年中南民族大学化学与材料科学学院调剂公告
已经有40人回复
-
武汉纺织大学招生物材料、化学、高分子相关专业硕士生
已经有0人回复
-
武汉纺织大学招生物材料、化学、高分子相关专业硕士生-另有少量士兵计划可咨询
已经有0人回复
-
[武汉纺织大学]材料学院[姜伟团队名称]课题组-2026年硕士研究生调剂信息
已经有0人回复
chemin
铁杆木虫 (职业作家)
- 应助: 9 (幼儿园)
- 贵宾: 0.05
- 金币: 8933.7
- 红花: 8
- 沙发: 4
- 帖子: 3405
- 在线: 272.3小时
- 虫号: 423181
- 注册: 2007-07-21
- 性别: GG
- 专业: 化学生物学与生物有机化学
2楼2007-11-21 22:16:42
3楼2007-11-22 05:33:14
