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求助完成,谢谢了(另一篇)
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我的学校没有CA,请帮我用CA检索一下关于分子式为C17H14O4化合物的所有文献,谢谢了.工作量很大,谢谢了 [ Last edited by hailiu on 2007-11-16 at 12:19 ] |
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hailiu(金币+48,VIP+0):非常感谢,还清你多多帮忙啊
hailiu(金币+48,VIP+0):非常感谢,还清你多多帮忙啊
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符合该分子式的我查了18个。 见http://www.isload.com.cn/store/kf5cco7fsevah 参考文献附后http://www.isload.com.cn/store/0pnskceob7zwv。 |
6楼2007-11-16 10:25:25
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hailiu(金币+2,VIP+0):谢谢 你的回复
hailiu(金币+2,VIP+0):谢谢 你的回复
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化学名:methyl (E)-3-(4-benzoylphenyl)-2-propenoate 结构式:  分子式:C17H14O3 分子量:266.2993 来源: ******************************************************************************* 合成情况： 目标产物：SB-RA-131012 合成路线:  合成方法：Palladium-catalyzed coupling of 4-bromobenzophenone (I) with methyl acrylate (II) afforded 4-benzoylcinnamic ester (III), which was hydrolyzed to acid (IV) with NaOH. Condensation with taxane derivative (V) in the presence of DCC and DMAP then provided the target ester. 参考：Bernacki, R.J.; Ojima, I. (State University of New York, Albany); Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compsns. thereof. EP 0966456; US 5811452; WO 9830553 -------------------------------------------------------------------------------- 目标产物：SB-RA-31012011 合成路线:  合成方法：Heck coupling between 4-bromobenzophenone (VIII) and methyl acrylate (IX) in the presence of palladium diacetate gave the unsaturated ester (X). Subsequent basic hydrolysis of the methyl ester group of (X) yielded p-benzoylcinnamic acid (XI). The title compound was then obtained by the coupling of acid (XI) with the precursor baccatin (VII) in the presence of EDC and DMAP. 参考：Strum, M.; et al.; Synthesis and SAR of new taxane reversal agents. 221st ACS Natl Meet (April 1 2001, San Diego) 2001, Abst MEDI 131 [ Last edited by wangzewen on 2007-11-15 at 22:16 ] |
3楼2007-11-15 22:12:22
