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[求助]
求助：药化合成工艺方面的期刊
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说明一下： 本人做药物合成工艺方面的研究，发文章较为困难，为了毕业，自己设计了条新的合成路线，其中一步用到生物酶催化，可是效果并没有预想的要好，转化率很低，ee值还行（生物酶是买的，不可能去进行酶的改造了），从工艺角度讲，肯定是不行的，当初考虑的就是用来发文章的，想问下大牛们，这种情况能发表个什么水平的文章？内心希望是个SCI收录的，非常感谢！ |
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【答案】应助回帖
感谢参与，应助指数 +1
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Organic Process Research & Development Papers may deal with the following areas.: Organic Process Research: Authors are encouraged to discuss synthetic route strategy and design, giving reasons and rationale (particularly issues relating to Scale Up and manufacture) for choice of reagents, solvents, conditions, etc., and highlighting unexpected differences observed as processes are scaled up. Organic Process Development: Authors may discuss the development and optimisation of research laboratory methods to make them more suitable for Scale Up and manufacture. Aspects which may be important include yield improvement, cost reduction, improvement in space-time yield, quality issues, structure and control of impurities, changes in yield/quality with reaction conditions, choice of solvent, workup and product isolation, safety, and environmental considerations. Authors may wish to include details of statistical methods of optimisation used (e.g., experimental or factorial designs, simplex methods, response surfaces). Other suggested topics include conversion of stoichiometric processes to catalytic methods and comparisons of methodologies for achieving a synthetic transformation, based on Scale Up considerations (including safety and environmental concerns). Scale Up Issues: Included in this area are topics related to choice of equipment for Scale Up, chemical reaction engineering issues (heat transfer, kinetics, mass transfer, mixing and agitation, unit operations), process control and instrumentation, separations technology, and process modeling. Safety Issues: This section will include papers discussing handling of toxic products and byproducts and thermal hazard testing of processes (including detailed studies on particular chemical reactions). Experiences of incidents and accidents, potential runaway reactions, and reactions where control is a problem (pressure buildup, excessive gas evolution, etc.) are particularly welcomed, especially where a detailed follow-up investigation has been carried out. The editors encourage scientists and engineers to publish this data to disseminate information as widely as possible, thus preventing further incidents and accidents elsewhere. Environmental, Waste Minimisation, and "Benign" or "Green" Chemistry Related Topics: Authors are encouraged to report their solutions to potential environmental issues in the fine chemicals industry, both reduction-at-source strategies and "end-of-pipe" solutions. Legislation, Regulatory, and Patent Issues: The Journal will try to highlight new legislation or changes which affect process R & D in the fine chemicals industry. However, authors are encouraged to report on their organisation’s approach to compliance with new or existing legislation on safety, environmental, and quality issues, GMP, validation of processes and equipment, etc., or on patent issues. Miscellaneous: In addition to these topics, the Journal encourages papers dealing with other subjects which fall within the scope of the objectives of the Journal. Examples not listed earlier include the following: the translation of a batch or semibatch process to a continuous process, crystallisation and polymorphism of new products, enzymatic methods for production of fine chemicals, new technologies, multipurpose techniques, and pilot plant design. |
2楼2013-08-20 08:46:18