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aa5288

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[求助] 线粒体DNA

请问各位怎么理解线粒体DNA的异质性(Heteroplasmy)和同质性(Homoplasmy)。谢谢!!!
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zhtear99

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【答案】应助回帖

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hanches: 金币+2, 师傅的应助奖励~~~ 2013-08-17 22:26:23
aa5288: 金币+8, ★★★很有帮助 2013-08-20 10:38:53
Homoplasmy refers to a cell that has a uniform collection of mtDNA: either completely normal mtDNA or completely mutant mtDNA.
A cell can have some mitochondria that have a mutation in the mtDNA and some that do not. This is termed heteroplasmy. The proportion of mutant mtDNA molecules determines both the penetrance and severity of expression of some diseases.
来自网址:http://hihg.med.miami.edu/code/h ... geContent.asp?ID=20
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2楼2013-08-17 15:10:24
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