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求助，罗非昔布的合成和制备
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2楼2007-11-12 09:56:17
3楼2007-11-12 14:41:55
Title rocess for making phenyl heterocycles useful as COX-2 inhibitors Author:Tillyer, R.; Desmond, R.; Dolling, U.; Marcune, B.; Tschaen, D. (Merck & Co., Inc.) Publication:WO 9608482 Text:The synthesis of rofecoxib can be performed by several different ways: 1) The condensation of phenylacetic acid (I) with ethyl bromoacetate (II) by means of triethylamine in THF yields 2-(phenylacetoxy)acetic acid ethyl ester (III), which is cyclized t Title:Synthesis of rofecoxib, (MK 0966, Vioxx(R)) 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone), a selective and orally active inhibitor of cyclooxygenase-2 Author:Th?ien, M.; Gauthier, J.Y.; Leblanc, Y.; Leger, S.; Perrier, H.; Prasit, P.; Wang, Z. Publication:Synthesis (Stuttgart) [ Last edited by biner2007 on 2007-11-15 at 09:19 ] |
4楼2007-11-15 09:18:29
xzh98
木虫 (小有名气)
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5楼2007-11-15 17:41:10