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| Lessons learned from the preclinical and clinical development of GSIs may offer some clues for a potential path forward. Since it is generally believed that the outcome of Notch signaling is dependent on context and the degree of activation, it is possible that partial pathway inhibition might ameliorate the toxicities associated with stringent and continuous pathway blockade while maintaining efficacy. |
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yin198716(phu_grassman´ú·¢): ½ð±Ò+10, ·ÒëEPI+1, ten BBs for your ten minutes 2013-09-23 08:15:17
yin198716(phu_grassman´ú·¢): ½ð±Ò+10, ·ÒëEPI+1, ten BBs for your ten minutes 2013-09-23 08:15:17
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