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[原创翻译]非甾体类抗炎药对帕金森病可能有保护作用
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NEUROLOGY 2007;69:1836-1842 © 2007 American Academy of Neurology Nonsteroidal anti-inflammatory drugs may protect against Parkinson disease Objective: Markers of neuroinflammation, including activated microglia and increased levels of circulating proinflammatory cytokines, have been observed in the brains and CSF of patients with Parkinson disease (PD). 目的：研究发现，在帕金森病（PD）患者的脑组织和脑脊液中存在炎症反应，表现为活化的小胶质细胞和促炎细胞因子水平增高。 Yet the link between anti-inflammatory agents and PD in humans remains uncertain, despite indications that neuroinflammation may contribute to cell death in the PD brain and experimental evidence of anti-inflammatory agents such as nonsteroidal anti-inflammatory drugs (NSAIDs) exerting neuroprotective effects in animal models. 虽然抗炎药对帕金森病的作用尚不肯定，但已有证据表明神经系统炎症可能导致PD患者脑部细胞死亡；而且动物实验证实非甾体类抗炎药（NSAIDs）等抗炎药有神经保护的作用。 Methods: Using a population-based approach, we studied NSAID use among 293 incident idiopathic PD cases and 286 age-, race-, and gender-matched controls from three rural California counties. 方法：运用人群调查的方法，对服用NSAIDs的293例原发性帕金森病患者病历资料和来自加利福尼亚州三个县的年龄、种族、性别配对的286例对照组的进行研究。 Results: Our data suggested a decreased risk of PD among regular (2 pills/week for at least 1 month) aspirin NSAID users (OR, 0.80; 95% CI, 0.56 to 1.15). 结果：数据显示，规律使用阿司匹林（每周2片，持续至少1月）降低罹患PD的风险。 A stronger protective effect was observed for regular nonaspirin NSAID users (OR, 0.52; 95% CI, 0.35 to 0.79), particularly those who reported 2 or more years of use (OR, 0.44; 95% CI, 0.26 to 0.74). 而在那些服用非阿司匹林非甾体类抗炎药2年或以上的使用者显示更强的保护作用。 The aspirin effect estimates differed by gender, showing a protective effect only in women, especially among long term (24 months) regular users (OR, 0.51; 95% CI, 0.26 to 1.02). 阿司匹林的保护作用和性别有关，仅对女性有益，尤其是长期（2年）规律服用者。 Conclusion: Our study contributes to the growing body of literature suggesting a protective role for nonsteroidal anti-inflammatory drugs (NSAIDs) in Parkinson disease (PD). 越来越多的文献报道NSAIDs对PD的保护作用，我们的研究证实了这一点。 Given our results and the biologic plausibility of a neuroprotective function for NSAIDs there is a pressing need for further studies elucidating the protective role such drugs may play in PD. 根据我们的研究结果和NSAIDs神经保护功能的生物学可能性，迫切需要进一步的研究说明这类药物在PD中的保护作用。 |
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