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[原创翻译]老年人阻塞性睡眠呼吸暂停与癫痫相关性研究
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NEUROLOGY 2007;69:1823-1827 © 2007 American Academy of Neurology Obstructive sleep apnea is associated with seizure occurrence in older adults with epilepsy Background: Although epileptic seizures occur more commonly in older adults, their occurrence in this age group is often unexplained. One unexplored precipitant of seizures in older adults is obstructive sleep apnea (OSA), which is also more common in this age group. Our objective was to investigate whether OSA is associated with seizure exacerbation in older adults with epilepsy. 背景：虽然痫样发作在老年人非常常见，但却难以解释。睡眠呼吸暂停（OSA）也常发生于这一年龄段的老年人。我们研究的目的在于观察二者之间的相关性。 Methods: Polysomnography was performed in older adult patients with late-onset or worsening seizures (Group 1, n = 11) and those who were seizure-free or who had improvement of seizures (Group 2, n = 10). 方法：晚发或加重的老年癫痫患者为一组（组1，n＝11），没有癫痫发作或减轻的老年人为一组（组2，n＝10），分别监测多导睡眠图。 Results: Patients in Group 1 had a significantly higher apnea-hypopnea index than patients in Group 2 (p = 0.002). Group 1 patients also had higher Epworth Sleepiness Scale scores (p = 0.009) and higher scores on the Sleep Apnea Scale of the Sleep Disorders Questionnaire (p = 0.04). The two groups were similar in age, body mass index, neck circumference, number of antiepileptic drugs currently used, and frequency of nocturnal seizures. 结果：组1患者比组2患者的呼吸暂停指数显著增高（p = 0.002）、Epworth嗜睡量表评分增高（p = 0.009）、睡眠障碍问卷的睡眠呼吸暂停评分增高（p = 0.04）。两组在年龄、身体指数、颈部周径、近期抗癫痫药使用数量、夜间发作频率无差异。（奇怪，第2组不是没有癫痫或癫痫好转的患者吗？后面两项怎么会没有差异？） Conclusions: Obstructive sleep apnea is associated with seizure exacerbation in older adults with epilepsy, and its treatment may represent an important avenue for improving seizure control in this population 结论：阻塞性睡眠呼吸暂停与老年性癫痫加重有关，针对阻塞性睡眠呼吸暂停的治疗可能是这一人群进一步控制癫痫发作的一条重要途径。 |
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