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Postranslational modification of Notch receptors by Fringe familyglycosyltransferases, which enhances Delta-mediated Notch activation but strongly weakens the signaling capability of Jagged1, are critical for the opposing roles of the two ligands¡£Jagged1 and Dll4 not only maintain differential Notch signaling among tip and stalk cells, they also control the levels of VEGF receptor expression and thereby EC growth and proliferation throughout the angiogenic vasculature |
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jiangguofeng
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yin198716: ½ð±Ò+10, ·ÒëEPI+1 2013-08-11 00:19:32
yin198716: ½ð±Ò+10, ·ÒëEPI+1 2013-08-11 00:19:32
| NotchÊÜÌå¾±ßÔµ¼Ò×åÌÇ»ù×ªÒÆÃ¸µÄ·ÒëºóÐÞÊÎÔöÇ¿Á˦Ä-½éµ¼µÄNotch¼¤»î×÷Óõ«ÊÇÈ´¼«´óµØÏ÷ÈõÁËJagged1µÄÐźŴ«ËÍÄÜÁ¦,Õâ¶ÔÁ½¸öÅäÌåµÄ¶Ô¿¹×÷ÓÃÀ´ËµÊǹؼüµÄ¡£Jagged1ºÍDll4²»½öά³Ö¶Ëϸ°ûºÍ±úϸ°ûÖ®¼ä²»Í¬µÄNotchÐźŴ«ËÍ,»¹µ÷ÕûÁËVEGFÊÜÌå±í´ï´Ó¶øÔÚÕû¸öѪ¹ÜÉú³ÉÆÚ¼äά³ÖECÉú³¤ºÍ·±Ö³ |
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