Znn3bq.jpeg
²é¿´: 604  |  »Ø¸´: 2
µ±Ç°Ö»ÏÔʾÂú×ãÖ¸¶¨Ìõ¼þµÄ»ØÌû£¬µã»÷ÕâÀï²é¿´±¾»°ÌâµÄËùÓлØÌû

Lewandowski

гæ (³õÈëÎÄ̳)

[ÇóÖú] ÇóÖú·­Òë

Recently, Sirt1 has been shown to inhibit Notch signaling in the stalk cell and thus provide a mechanism by which Notch signaling can be fine-tuned. Sirt1, a deacetylase, was shown to deacytelate the Notch1-ICD to promote its ubiquitin-mediated degradation and thereby down-regulate Notch-mediated gene transcription. To fully understand the role of Notch in regulating sprouting angiogenesis, future work will need to focus on the cellular mechanisms that modify Notch signaling to allow for the dynamic cellular identities of the nascent sprout.

» ²ÂÄãϲ»¶

ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

¹¸ÛСº¢

½ð³æ (СÓÐÃûÆø)

¡¾´ð°¸¡¿Ó¦Öú»ØÌû

¡ï
Lewandowski(RXMCDM´ú·¢): ½ð±Ò+1, ¶àлӦÖú£¡ 2013-12-31 01:04:08
½üÀ´ÓÐÑо¿Ê¹ÓÃSirt1ÒÖÖÆÔÚ±úϸ°ûÖеÄNotchÐźţ¬ÒÔ´ËÌṩÄÜʹNotchÐźÅ΢µ÷µÄ»úÖÆ¡£Sirt1£¬ÍÑÒÒõ£»ùø£¬±»ÓÃÀ´ÍÑÈ¥Notch1-ICDµÄõ£»ù£¬ÒÔ´Ù½øÆäÒÔ±éÔÚµ°°×ÖÊΪý½éµÄÍË»¯£¬ÓÉ´Ëϵ÷ÒÔNotchΪý½éµÄ»ùÒòת¼¡£ÒªÍêÈ«Àí½âNotchÔÚµ÷½ÚѪ¹ÜÉú³ÉÖеÄ×÷Óã¬Î´À´µÄ¹¤×÷½«ÐèÒª¼¯ÖÐÔÚÐÞ¸ÄNotchÐźŵĻúÖÆ£¬ÒÔ¿¼Âǵ½ÐÂÉúÆÚµÄ¶¯Ì¬Ï¸°ûͬһÐÔ¡£

ÎÒÒ²²»ÊÇרҵµÄ£¬¹þ¹þ¡£
3Â¥2013-08-30 13:04:09
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
²é¿´È«²¿ 3 ¸ö»Ø´ð

liting123

Ìú³æ (СÓÐÃûÆø)

¡¾´ð°¸¡¿Ó¦Öú»ØÌû

¡ï
Lewandowski(RXMCDM´ú·¢): ½ð±Ò+1, ¶àлӦÖú£¡ 2013-12-31 01:04:25
×î½ü£¬Sirt1 ±»·¢ÏÖ¾ßÓÐÒÖÖÆÇпÚÔÚ¾¥Ï¸°ûÄÚ·¢³öÐźţ¬´Ó¶øÎªÇпÚÐźŵķ¢³öÌṩÁËÒ»Öֺõĵ÷Õû»úÖÆ¡£Sirt1,×÷Ϊ Ò»ÖÖÍÑÒÒõ£Ã¸£¬±»·¢ÏÖÄÜÍÑÈ¥ ÇпÚ1-ICD ÖеÄõ£»ù£¬ÕâÑùÒ»À´£¬¾Í»á´Ù½øËüµÄ·ºËؽ鵼ÍË»¯£¬Òò´ËÄÜϵ÷Çпڽ鵼 »ùÒòת¼¡£ÒªÍêÈ«Á˽âÇпÚÔÚµ÷½Ú³öѿʽѪ¹ÜÉú³ÉÖеÄ×÷Óã¬Î´À´µÄ¹¤×÷ÐèÒª¼¯ÖÐÔÚÒ»ÖÖϸ°û»úÖÆÉÏ£¬ÕâÖÖϸ°û»úÖÆÄܵ÷ÕûÇпÚÐźŵķ¢³ö£¬Ê¹³õÆÚÐγɵÄÑ¿ÖоßÓж¯Ì¬µÄϸ°ûÌØÐÔ¡£


ps: ¶ÔÉúÎﲻ̫Á˽⣬¿ÉÄÜ·­ÒëµÄ²»×¨Òµ£¬Ï£ÍûÓаïÖú¡£
2Â¥2013-08-29 22:03:17
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] 297£¬¹¤¿Æµ÷¼Á? +5 ºÓÄÏũҵ´óѧ-ÄÜ 2026-04-14 5/250 2026-04-18 15:17 by Equinoxhua
[¿¼ÑÐ] Çóµ÷¼Á +9 СÄô°®Ñ§Ï° 2026-04-16 11/550 2026-04-17 22:34 by chixmc
[Óлú½»Á÷] ¶þ±½¼×ͪËáÀàÑÜÉúÎï 50+3 С°×°®Ö÷ÈË 2026-04-17 6/300 2026-04-17 18:47 by kf2781974
[¿¼ÑÐ] 295·ÖÇóµ÷¼Á +5 ?ÒªÉϰ¶? 2026-04-17 5/250 2026-04-17 16:51 by fenglj492
[¿¼ÑÐ] 335Çóµ÷¼Á +20 ÏëÉϰ¶Ñ½£¡£¡ 2026-04-12 23/1150 2026-04-17 10:50 by cuisz
[¿¼ÑÐ] 291Çóµ÷¼Á +9 ¹ØÒä±±. 2026-04-14 9/450 2026-04-16 22:49 by cfdbai
[¿¼ÑÐ] Ò»Ö¾Ô¸»¦9£¬ÉúÎïѧ326Çóµ÷¼Á +9 Áõīī 2026-04-15 9/450 2026-04-16 17:14 by ´Þ´Þ´Þcccc
[¿¼ÑÐ] 26ҩѧר˶105500Çóµ÷¼Á +6 à¶¹þ¼ÓÓÍ 2026-04-13 7/350 2026-04-16 14:31 by zhouxiaoyu
[¿¼ÑÐ] 322Çóµ÷¼Á +8 123°²¿µ 2026-04-12 15/750 2026-04-16 11:07 by Espannnnnol
[¿¼ÑÐ] Ò»Ö¾Ô¸AÇø211£¬22408 321Çóµ÷¼Á +6 ËæÐÄËùÓû¡î 2026-04-15 7/350 2026-04-15 21:45 by lbsjt
[¿¼ÑÐ] ÉúÎïѧµ÷¼Á +9 Ö½ÉÈzhishan 2026-04-13 9/450 2026-04-15 18:28 by ANÁ÷800
[¿¼ÑÐ] 0854µ÷¼Á +13 ³¤¹­°Á 2026-04-12 16/800 2026-04-15 13:45 by fenglj492
[¿¼ÑÐ] 085408¹âµçÐÅÏ¢¹¤³Ìר˶355Ò»Ö¾Ô¸³¤´º¹â»úËùµ÷¼Á +6 Íõymaa 2026-04-13 13/650 2026-04-14 11:33 by Íõymaa
[¿¼ÑÐ] ¿¼ÑÐÓ¢Ò»ÊýÒ»338·Ö +9 ³¤½­´óѧ¶«Ð£Çø 2026-04-13 10/500 2026-04-14 00:41 by Íõ¬Bè±
[¿¼ÑÐ] 2026˶ʿµ÷¼Á_Äܶ¯_ºÓÄÏũҵ´óѧ +4 ºÓÄÏũҵ´óѧ-ÄÜ 2026-04-12 4/200 2026-04-13 22:01 by bljnqdcc
[¿¼ÑÐ] 293Çóµ÷¼Á +16 ÎÒ°®¸ßÊý¸ßÊý°®Î 2026-04-12 18/900 2026-04-13 21:47 by ѧԱJpLReM
[¿¼ÑÐ] 302Çóµ÷¼Á +10 Ò×£¡? 2026-04-13 10/500 2026-04-13 19:04 by lbsjt
[¿¼ÑÐ] 297¹¤¿Æ£¬Çóµ÷¼Á? +13 ºÓÄÏũҵ´óѧ-ÄÜ 2026-04-12 13/650 2026-04-13 14:12 by dingyanbo1
[¿¼ÑÐ] 346·Ö£¬¹¤¿Æ0854Çóµ÷¼Á£¬×¨Ë¶ +6 moser233 2026-04-12 7/350 2026-04-12 22:11 by fqwang
[¿¼ÑÐ] µ÷¼Á½áÊø +6 floriea 2026-04-12 8/400 2026-04-12 18:13 by zhouxiaoyu
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û