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Lewandowskiгæ (³õÈëÎÄ̳)
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| Recently, Sirt1 has been shown to inhibit Notch signaling in the stalk cell and thus provide a mechanism by which Notch signaling can be fine-tuned. Sirt1, a deacetylase, was shown to deacytelate the Notch1-ICD to promote its ubiquitin-mediated degradation and thereby down-regulate Notch-mediated gene transcription. To fully understand the role of Notch in regulating sprouting angiogenesis, future work will need to focus on the cellular mechanisms that modify Notch signaling to allow for the dynamic cellular identities of the nascent sprout. |
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Lewandowski(RXMCDM´ú·¢): ½ð±Ò+1, ¶àлӦÖú£¡ 2013-12-31 01:04:08
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