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| In addition, DLL4-blocking agents have been shown to lack the adverse effect of goblet cell metaplasia, which is a dose-limiting factor for GSIs. Thus, DLL4 inhibitors appeared to be a promising agent for cancer therapy. However, it has been shown that chronic Dll4 inhibition can cause pathological activation of endothelial cells and consequently vascular neoplasms. |
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yin198716: ½ð±Ò+5, ·ÒëEPI+1 2013-08-03 00:47:01
yin198716: ½ð±Ò+5, ·ÒëEPI+1 2013-08-03 00:47:01
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