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China Novartis Institutes for BioMedical Research Co., Ltd. (CNIBR) has some job vacancies as below. If you have interested in these jobs, please send your resume with no hesitation cause we'll provide you more chance to promote yourself in your field. (Sr.) Investigator, Medicinal Chemistry Investigator, Bioinformatics Investigator II/III, Hair Cell Investigator, Epigenetics of Cancer Drug Discovery Investigator, Developmental Biology Scientist I/II, Cellular Assays Investigator, Computer-Aided Drug Design Clinical Trial Head Head of Scientific Operations For more details, please click our career website: http://careers.novartis.com.cn/vacancies.html To apply this position, please send your resume to sarah.qi@novartis.com When you send your resume to sarah.qi@novartis.com, please notice you know this position information via 小木虫BBS 诺华（中国）生物医学研究有限公司是诺华全球研发组织――诺华生物医学研究所（NIBR）的第八个研究基地。我们位于中国上海市张江高科技园区，将成为诺华在亚洲的主要研究中心，以及除在欧美的研究中心外的最主要的研究中心。我们的研究和探索开发活动的重点是发现并开发创新疗法，用于治疗在亚洲远未达到医药需求的疾病。我们与从不同之处在于将专注现代药物的发现和开发方法的研究。最初阶段，研发工作将专注在引起中国地方性癌症的感染原因。我们还将开展临床试验，进行安全性研究，生物标志物和检测分析，表达谱、生物分析以及转化医学的研究。 随着公司业务的迅速扩展，我们热忱欢迎您的加入。同时我们将提供具有竞争力的薪酬福利待遇以及良好的培训发展机会。 NIBR Shanghai NIBR Shanghai is an integrated research center that is part of the Novartis global research and development network. The establishment of this strategic site is a commitment by Novartis to conduct cutting-edge pharmaceutical research in China. Research activities at NIBR Shanghai focus on addressing urgent medical needs in China, particularly infectious causes of cancer endemic to the region. The center also established programs in epigenetics, biomarker development, drug metabolism and preclinical safety to support NIBR local and global R&D projects.Research at NIBR Shanghai is currently focused on discovering new therapies for infectious causes of cancer, such as liver cancer caused by HBV or HCV hepatitis. As the diseases are highly prevalent in the region, some one-third of the 400 million people infected with the hepatitis B virus are in China, with estimates that 300,000 people die from liver cancer in the mainland each year. A Growing and Dynamic Organization China Novartis Institutes for BioMedical Research Co., Ltd. (CNIBR), the legal entity for NIBR Research Center in Shanghai was launched in November 2006 and the start-up Research facilities opened in April 2007. Today, NIBR Shanghai has grown to an organization of about 260 associates including nearly 200 scientists. The research teams are comprised of both returnee scientists from abroad (about 20% of total scientists), and graduates from top tier universities, medical centers, and research institutes in China. Currently the center operates in an office building and two lab facilities in the Zhangjiang Hi-Tech Park. In the same area, the new Novartis Shanghai Campus is under design and construction. The first phase of the project will be completed by the end of 2014. [ Last edited by saliand on 2013-8-7 at 15:17 ] Investigator II Job Purpose Manage projects (with a TA focus), interpret and present information and negotiate an optimal PK/PD strategy for early and late development in liaison with TA-PK Head and appropriate line functions. Responsible for the PK, PK/PD and M&S component of study protocols, reports and project summaries within agreed timeframes and which meet regulatory requirements. Take the lead on appropriate pharmacokinetic /biopharmaceutical studies. Major Accountabilities • Define PK, PK/PD, biopharmaceutical and M&S requirements in project (nonclinical and clinical) development plans and appropriate strategies for global registration. • Analyze, interpret and represent PK, PK/PD and M&S data generated during development and provide guidance. • Proactively manage links with other functions to ensure that pre-clinical and clinical PK/PD information are used optimally. • Directly or indirectly take the lead on appropriate pharmacokinetic/biopharmaceutical studies. • Prepare summary information for internal and external Advisory panels, Investigator meetings and Health Authorities as part of the regulatory approval process. This includes PK/PD components of IND applications in the US, CTX in other countries. • Represent the PK/PD discipline and ensure high quality interactions with various health authorities, external investigators, and various internal Novartis Disease Area experts • Coordinate with appropriate sub-team members and other LF experts and/ or prepare (when needed) summary documentation on drug metabolism and pharmacokinetics as required by ethics committees and HAs (IB, BB, CTA/IND, responses to HAs). • Prepare, compile and review appropriate sections of CTD dossiers /NDA documents. • Contribute to and support continuous improvement initiatives in global pharmacokinetics and partner functions Ideal Background Education: Ph.D. in Pharmaceutical Sciences, or related disciplines (or equivalent degree/knowledge/expertise) Languages: fluent English and Chinese (spoken and written) Experience: 3-4 years of experiences in drug development or a relevant environment [ Last edited by saliand on 2013-10-12 at 17:49 ] |
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金虫 (小有名气)
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13楼2013-07-31 11:10:03
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Investigator II/III, Hair Cell Job Description: Explore the molecular mechanism underlying inner ear hair cell development and regeneration Elucidate the molecular mechanism of hair cell differentiation and transdifferentiation, genetic and epigenetic regulation of hair cell development and regeneration Minimum requirements: Ph.D. in Developmental Biology, Cell Biology or related fields or a Medical degree in Otolaryngology, minimal three years postdoc training Strong scientific capabilities as manifested by a strong publication record Previous experience in hearing research is required. Deep understanding of hair cell biology, particularly hair cell development and regeneration as well as hands on experience with primary tissue culture, organotypical culture, small animal surgery and molecular biology are required |
2楼2013-07-30 17:14:24
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Sr. Investigator, Medicinal Chemistry Job Description: Lead a group of medicinal scientists (Ph.D./MS) to support drug discovery research programs Design tool compounds and experiments to support target validity, drive hits to high quality leads and drug candidates by optimization of efficacy, ADME and safety Collaborate with scientists from other platforms in Novartis and external collaborators Minimum Requirements: Ph.D. in synthetic organic or medicinal chemistry; > 5 years of relevant experience in the major pharmaceutical industry or biotechs Experience in identifying hits for difficult targets by exploiting in silico methods, novel chemical libraries and structure based design, oncology and immunology experience as required Proven track record of innovative project contributions including peer-reviewed publications Ability to work independently and ability to collaborate with a multidisciplinary team, excellent oral/written communication and presentation skills [ Last edited by saliand on 2013-7-30 at 17:21 ] |
3楼2013-07-30 17:19:58
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Investigator, Bioinformatics Job Description: Data mining of large scale multi-omics data Integrating multi-omics data for drug discovery and biomarker development Developing useful computational tools and new algorithms for biological research Providing expert data-mining support to drug discovery and translational research Minimum requirements: Ph.D. in bioinformatics, computational biology, mathematics, computer science or other related fields Three or more years of relevant post-graduate research experience in bioinformatics data analysis Independent problem-solving capability Excellent skills in statistical software like R and/or Matlab Excellent programming skills with scripting language such as Perl and Python Experience with next-generation-sequencing data is essential Wide experience in genome-sequencing, ChIP-seq, transcriptomics, and proteomics, compound profiling analysis |
4楼2013-07-30 17:22:52
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Investigator, Epigenetics of Cancer Drug Discovery Job Description: Lead or contribute to drug discovery programs towards identification and validation of therapeutic targets, lead compounds, discovery and refinement of drug candidates, development and characterization of both predictive and pharmacodynamics biomarkers Responsible for Ph.D. scientists and scientific associates optimizing molecules toward oncology drug candidates Work with multi-site collaborative environment and academic investigators and CROs Minimum requirements: Solid education and training in Molecular, Cellular, cancer and/or developmental biology Proven track record of success in drug discovery Ph.D. or MD with postdoctoral experience in relevant field, with up to 8 years work experience is preferred |
5楼2013-07-30 17:27:40
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Investigator, Developmental Biology Job Purpose China NIBR based in Shanghai is dedicated to the research and development of products addressing diseases prevalent to China, and providing innovation in the understanding and curing of Epigenetic causes of diseases. Cell fate specification and differentiation of stem cells into distinct cellular lineages during mouse embryogenesis are tightly regulated genetically and epigenetically, particularly via the interplay between key development regulators and various epigenetic modulations. Such interaction and similar mechanisms are also manifested during regeneration and aging processes. Epigenetic dysregulation will cause abnormal embryonic development and various human diseases. To aid target discovery and mechanistic understanding of regeneration, we are inviting applications for an Investigator position in the regenerative medicine research group. The successful candidate will be part of the developmental biology core, focusing on novel target discovery and disease modeling for regenerative medicine. He/She will be responsible for elucidating the roles of key epigenetic regulators during development and regeneration by using combinatory mouse genetics and epigenomic profiling approaches. The successful candidate will also participate in multi- disciplinary drug discovery and development team to support target discovery in disease areas of focus. Minimum requirements • Ph.D. in Developmental Biology, Cell Biology or related fields, minimal three years postdoc training • Hands-on experience with mouse embryology, histology or pathology analysis; familiar with key developmental pathways such as Wnt, BMP, Notch etc. • Deep understanding of epigenetics and proficient in research technologies such as ChIP-Seq, and DNA methylation analysis are required. . • Highly self-motivated and highly collaborative team worker is essential. Previously industrial experience is preferable. [ Last edited by saliand on 2013-7-30 at 17:31 ] |
6楼2013-07-30 17:29:24
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Scientist I/II, Cellular Assays Job Purpose We are seeking an energetic, motivated scientist to join CNIBR to support drug discovery research in the epigenetics areas. A person in this role must be enthusiastic to contribute and share responsibilities with team members for biochemical and cell-based assay development and regular running. In addition, he/she will also be involved in epigenome profiling and mechanism studies on the specific epigenetic targets. Under the supervision of a senior scientist, the successful candidate is expected to work independently to execute, interpret and troubleshoot experiments. The successful candidate will also participate in multi- disciplinary drug discovery and develop all-around skills in the disease areas of focus in the long run. Minimum requirements • A MS degree in life science and 1+ years of drug discovery experience, or a PhD degree in Biological Science with proven record of accomplishment are necessary. • Experience with multiple cell based methods (Cell culture, RNAi technology, cell growth/proliferation assays, western blot, immunofluorescence, ELISA, real-time PCR) are required. Prior experience with small molecules handling and medium to high throughput screening are desired. Good understanding of enzymology is a plus. • The candidate must be highly self-motivated and have good communication skills to work in a collaborative team environment. Excellent writing and presentation skills, with good multi-tasking ability are needed. • Competences in maintaining lab notebooks and computer files are also required. |
7楼2013-07-30 17:31:38
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Investigator, Computer-Aided Drug Design Job Description: Employ CADD technology in support of drug discovery projects and work close with multidisciplinary drug discovery teams Suggest and develop new approaches leading to the identification of lead and optimization of the small molecule Design and maintain a cutting-edge CADD platform of relevant resources both in terms of software, chemical database and scientific information which will be actively used by the project Minimum Requirements: Ph.D. degree in computational chemistry, computational biology or a relevant field with at least two years industry experience In-depth knowledge and comprehension of CADD in drug discovery A proven track record in the use of standard CADD approaches Experienced in protein modeling, structural analysis, binding site mapping, docking and post-docking analysis, library design/ranking, and virtual screening Demonstrate skills in the fields of molecular dynamics Show know to how in the field of molecular descriptors (knowledge of existing fragment counts, pharmacophore fingerprints and design of new terms), and structure-activity relationships Demonstrated expertise in handling/maintenance of large databases, clustering, QSAR, and ADME optimization |
8楼2013-07-30 17:34:24
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Clinical Trial Head, OTM Job Description: Accountable for all aspects of assigned OTM clinical trials (Phase I/II) including leading Clinical Trial Team(s) (CTT) Lead the clinical protocol development process in collaboration with the Clinical Program Leader (CPL) Contribute to the development of clinical sections of regulatory documents, lead or be a key contributor to the development of program specific standards Investigator/site relationship management Lead and matrix manage the global multidisciplinary CTT to ensure all trial deliverables are met according to timelines, budget, and resource requirements In collaboration with the CPL lead the clinical trial data ongoing medical/scientific review, final analysis and interpretation Develop clinical outsourcing specifications to facilitate bid templates and selection of CROs and other 3rd parties Function as local trial leader (LTL) for all US US-based CTL activities Minimum Requirements: Advanced degree or equivalent education/degree in life science/healthcare strongly recommended, PhD preferred Fluent English (oral and written) ≥ 6 years technical, operational and managerial experience in planning, executing, reporting and publishing clinical studies in a pharmaceutical company or contract research organization Thorough knowledge of Good Clinical Practice, clinical trial design, statistics, regulatory processes, and global clinical development process Advanced knowledge of oncology and/or hematology, or experience in early clinical development |
9楼2013-07-30 17:39:25
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Head of Scientific Operations Job Purpose To lead and manage the scientific operations functions at NIBR Shanghai and provide high quality, value added support and services to NIBR Shanghai and, as a host, also to all other scientific divisions located in Shanghai campus Major Accountabilities • Overall leadership and and management of high quality, efficient services to support NIBR, TS, Vaccine Research, OTM, and other relevant site customers. Develop and implement the opera-tions strategy that can support both the current site as well as the future campus. The catego-ries of support include: o Animal Welfare and Compliance (AWC) o Archiving and Records Management (AR&M) o Health, Safety and Environment (HSE) & Business Continuity (BC) o Laboratory Animal Services (LAS): include providing guidance for vivarium and breeding strategy to support the current scientific community and future users o Laboratory Operations: Space planning, capital equipment management, and lab support services particularly: Research Support (Glass Wash, Media/Reagent Prep), site Cell banking Services. o Materials and equipment import and export, and development and management of key external stakeholders in government or commercial companies as related to im-portation and export o Scientific data Quality Assurance • Continually refine the breadth and depth of the service and support programs and drive best practices to ensure the most cost effective and efficient services are provided to NIBR Shanghai site – establish and maintain a strong partnership with all relevant internal customers • Manages personnel and financial resources to meet performance expectations including re-cruiting and hiring top quality talent for related areas. Prepares input to local budget to sup-port Global line functions. • Attract, motivate, and develop top talents in order to provide highest quality support, work with HR to bring satisfying work experience and career progression opportunity for the team • A member of the global Scientific Operations leadership team representing Shanghai site • Manage and maintain close interactions with other relevant support functions in Shanghai site, support, and where appropriate lead specific projects for local or global operations Minimum requirements Education (minimum/desirable):MS or Ph.D. Degree in science related field with 15+ years experience, MBA helpful but not required. Languages:English Experience: 10+ years supervisory/management experience, a range of Research and/or Development areas within the biotech/pharmaceutical industry including lab experience. Strong people, process and project management skills. Knowledge and understanding, experience of services provided in a scientific setting. Good working knowledge of lab operations and equipment managing/oversight of lab and support functions, lab equipment and facilities. Management of large/ international projects and good foundation in general management disciplines (HR, Finance etc). Experience of working in and leading teams on complex projects requiring local and global multi-disciplinary input in a matrix management setting |
10楼2013-07-30 17:43:34