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?????????????V?????磯?????????????V?????磯?????????????V???????磯?????????????V???????? -------------------------------------------------------------------------------- ????????????? ????2013??6????????????????4?棩 ??2013??3????????3?棩 ????????????????? 871179 ?????????????????? ?????????τ????????J???? ????2013??6????????????????V?????磩 ????2013??6????????????????V?????磩 ????2013??6????????????????V???????磩 ???H?Q?????? 2002??7?? ?a???????? ???????a ???J?? ????? ?????????????V?????? ????????`?? 1179045F4022 ???J??S????? ???J???? 22400AMX00030 ???????? ABILIFY OD tablets ?a????????d???? 2012??4?? ????_????? 2012??5?? ?A??????????? ?A?? ???±??? (???????Ф??????????`????Τ????椹????) ??????? ?u????2??6?w??(????????) ??? ??????C????m?????(??????V?????????餫??) ??????? ???a ?????????I????????????????? ?I????????a? ?M?? ?????? 1?V?С???????饾?`??3mg ?????? ???????D-?????`??????????`??(L-?????????????)???o????????? ??? ????????V(?????????V) ???? ???(mm) ?s10 ??(mm) ?s3 ???(mg) ?s12 ????? ?????????????V?????? ????????`?? 1179045F5029 ???J??S????? ???J???? 22400AMX00031 ???????? ABILIFY OD tablets ?a????????d???? 2012??4?? ????_????? 2012??5?? ?A??????????? ?A?? ???±??? (???????Ф??????????`????Τ????椹????) ??????? ?u????2??6?w??(????????) ??? ??????C????m?????(??????V?????????餫??) ??????? ???a ?????????I????????????????? ?I????????a? ?M?? ?????? 1?V?С???????饾?`??6mg ?????? ???????D-?????`??????????`??(L-?????????????)???o????????? ??? ????????V(?????????V) ???? ???(mm) ?s12 ??(mm) ?s3 ???(mg) ?s23 ????? ?????????????V???????? ????????`?? 1179045F6025 ???J??S????? ???J???? 22400AMX00032 ???????? ABILIFY OD tablets ?a????????d???? 2012??4?? ????_????? 2012??5?? ?A??????????? ?A?? ???±??? (???????Ф??????????`????Τ????椹????) ??????? ?u????2??6?w??(????????) ??? ??????C????m?????(??????V?????????餫??) ??????? ???a ?????????I????????????????? ?I????????a? ?M?? ?????? 1?V?С???????饾?`??12mg ?????? ???????D-?????`??????????`??(L-?????????????)???o????????? ??? ????????V(?????????V) ???? ???(mm) ?s14 ??(mm) ?s3 ???(mg) ?s35 ????? ?????????????V???????? ????????`?? 1179045F7021 ???J??S????? ???J???? 22400AMX00033 ???????? ABILIFY OD tablets ?a????????d???? 2012??4?? ????_????? 2012??5?? ?A??????????? ?A?? ???±??? (???????Ф??????????`????Τ????椹????) ??????? ?u????2??6?w??(????????) ??? ??????C????m?????(??????V?????????餫??) ??????? ???a ?????????I????????????????? ?I????????a? ?M?? ?????? 1?V?С???????饾?`??24mg ?????? ???????D-?????`??????????`??(L-?????????????)???o????????? ??? ????????V(?????????V) ???? ???(mm) ?s18 ??(mm) ?s5 ???(mg) ?s71 ???????? ??????饾?`?? Aripiprazole |
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???? 1. ??????????????`???????????????????????????????????????????k?F????????????Τ??????????Ф???????????????????????????????????μ????s?????????Σ???????Ф?????????????????????Σ??????????ж????????Τ?????????????????????????????Μy??????Q????????Ф?????? 2. ???????????????餫???????????????k?F???????????????????????μ?????????h????????f???????????l???????????е???????????????Τ褦?????????????????????????????ж??????????\????????褦????????????(????????? 4.????????????????????? 4.??6.??????????????á?????????? 6.??????????????`??????????????????????) ???? ???Τλ???????????????? 1. ?????B?λ????????B?????????????????????? 2. ?Х???`?????T????????E???????????U??????????????¤?????????????U???????????????????????????? 3. ?????????????Фλ???(???????á???????) 4. ?????γ???????^????μ????s?Τ????? ??????τ??? ?????????????OD?V3mg???OD?V6mg???OD?V12mg ??y????{? ????O?????????????????θ??? ???????????????B????????????????????J?????????????? ?????????????OD?V24mg ??y????{? ????O?????????????????θ??? ????????????????v?B????????????? ???????????????B????????????????????J??????????????????? 1. ?????x?k???????????????z???躦??????????????Υ?????????????z???躦????????m?Ф???????Ф?????????????J??????????????????????????????????? 2. ???????????????????24?r???¤λ??????????]?????????Υ???????????????椬?????????????????????????????????????]??????????????????????5.????????? ?÷????????? ??y????{? ????????????????饾?`??????1??6??12mg???_???????1??6??24mg??S???????????1?????2???????U???????????????h?????????m?ˉ??p??????1??????30mg??????????? ????O?????????????????θ??? ????????????????饾?`??????12??24mg??1??1??U?????????????_???????24mg????????h?????????m?ˉ??p??????1??????30mg??????????? ???????????????B????????????????????J?????????????? ????????????????????饾?`??????3mg??1??1??U???????????????h?????????m?ˉ??p??????????????1?????????3mg?????1??????15mg??????????? ?÷????????????v?B????????????? ????????? ????????????B???_???????s2?L?g?????????2?L?g????ˉ??????????????????????(???a???B????????) ??y????{?????? (1) ?????????????????С?????褦????????????????Q????????{?????????(???????????????????^??????????????R?????????????) (2) ???ο??????a???鱾???ˉ????????????¤???y????{?????????_???????????????k?F?????????????Τ褦???????????????????Q??????????????{????????? ????O?????????????????θ??????? ?????????????????????????????@?A??????????????????????????????????褦???????? ??????????V?Τ???????? ????????????????????????????????Τ?(????)????????????????????????????????????k?F??????????u??????????????????????????????z????? ???????????????B????????????????????J??????????????????? ???????????x?k???????????????z???躦??????????????Υ?????????????z???躦?????????????????????????????B???????????g?????????????_?J??????????????R?????????????? ????????? ??????? ???Τλ?????????????????? 1. ??????Τ???????????????????????????????? 2. ???????????????R????????????Τ????????^?????R???¤?????????????????? 3. ??????d??????????????μ????s?Τ??????d??铂?????¤?????????????? 4. ?????????μ????s???Ф????????????????μ???s???????????????????Σ???????Ф??????????????N?????????????(?????桳??????????????????? 4.??6.??????????????á?????????? 6.??????????????`??????????????????????) 5. ?????????]??????????μ????Τ???????????]?Τ???????????]?????????????????????????? 6. ????×?????|??????Τ????????????????????????????? 7. ?????n?????????????????Ф????????????????????????????? 8. ???h??(?????h?????????????) ????????????? 1. ??????????????????????\????????ε??¤???????????Τ??????????Фλ????????????\???Σ??餦?Cе?β????????¤???????褦???????? 2. ?y????{????????????a??????Ф??椨???H???d?^???????F?????ξ??????????????????????Τ???Q????????Ф???????????a????????????p?餷???????????????Ф??????????????????????????????????????????????????Ф??椨?????m?Ф?I????Ф?????? 3. ???????????????d?^????????????????????????????????????????????????????悾????????????????I???????]??????? 4. ??????????????`???????????????????????????????????????????k?F????????????Τ??????????Ф????f???????????l???????????е?θ????????????????????????????????μ????s?????????Σ???????Ф?????????????????Μy??????Q????????Ф??????(?????桳????????????? 4.??????????????á?????????? 6.??????????????`??????????????????????) 5. ????????????????????Τ??????????Ф???????С????С??亹????顢?A??????R?????ε???????????????????????Μy??????Q????????Ф??????(???????á?????????? 7.????????????) 6. ???????????H???????餫???????4.????5.?θ???????k?F???????????????????????μ?????????h?????????????(??f???????????l???????????е?)?????????(?????С????С??亹????顢?A??????R?????)??????????Τ褦?????????????????????????????ж??????????\????????褦????????????(?????桳????????????? 4.??????????????á?????????? 6.??????????????`????????????????7.????????????) 7. ????????????????B???Ф???????????????????????¤ε?????????? (1) ????????????????????????]?????????????Τ?????????Τ?????Τ褦??????????_???????????????????????H?????????B??????B??仯????????Q??????? (2) ???????????????d?^????????k????????????????????????????n??????????????????????\????g???????????????椵???????????????v?S?????餫??????????????????????????????????????????A??????????????????]???????????????О餬??椵?????????????B??????B??仯????????Q?????????????????????????Q??????????????a????????????????p????????????????m?Ф?I????Ф?????? (3) ?????????????^??????????????????A???J????????I????????????1????I??????????С?????????? (4) ???????????????]???????????d?^?????????????????????仯??????A???????????????????????????????h?????Ф????????o????B?j????????褦?????????? 8. ???????????????????(??????p??)???????????????Τ??????????Ф?????????????????Q?????????????J??????????????(???????????Пo??)??g???????????????m?Ф?I????Ф?????? 9. ???ο??????a????????????????????饯??????????????????????????????????饯???????????¤???U?????_???????????Τ????U?^????????m????????k?F????????????? 10. ??????????k?F????????????Τ??????`???????Υ????Τ???????????????????????????U?^???Q??????? 11. ???????a???????????????????}????????????????椵??????Τ????????B???L???P??????????????B???Σ???????Ф????????????????????????(???????á?????????? 10.?????????????}???????????) ?????? ??????θ??? ??????????????δ??x????CYP3A4????CYP2D6????x?????(???a???B????????) |
3楼2013-07-26 14:44:44
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??????? ??????????????? 1. ?a?????? ?????????? ???????? ?R????????÷??? ?????????????????????????R???¤?????????????? ?C???Σ????? ?????????????????????????????????δ??????????????Φ?????????????????????????????????λ??????R?????????????????? ??????? ??????????????? 1. ?a?????? ????????U????? ???Х???`?????T???塢???E???? ?R????????÷??? ??????U?????????????Τ???p???????????????? ?C???Σ????? ??????????U??????????Ф??? 2. ?a?????? ?????R?? ?R????????÷??? ??????R??????????????????Τ???p????????????????????? ?C???Σ????? ??????R??????Ф??? 3. ?a?????? ???????????????Ф????a?? ?R????????÷??? ???????????????????????????Τ???p????????????????????? ?C???Σ????? ????????????????Ф??? 4. ?a?????? ????????????a ????????u?? ?R????????÷??? ??????????????p??????????????Τ??????????{????????????????????? ?C???Σ????? ?????????????????????????Ф??? 5. ?a?????? ???????`??(??) ?R????????÷??? ??????????U???????????????????????? ?C???Σ????? ??????????U??????????Ф??? 6. ?a?????? ??CYP2D6?躦??????Ф????a?? ???????????????????????? ?R????????÷??? ???????????????????????????Τ????????p??????????]??????? ?C???Σ????? ????????????x????????CYP2D6???躦???????????????????N???????????? (???a???B????????) 7. ?a?????? ??CYP3A4?躦??????Ф????a?? ??????饳????`???????????`??? ?R????????÷??? ???????????????????????????Τ????????p??????????]??????? ?C???Σ????? ????????????x????????CYP3A4???躦???????????????????N???????????? (???a???B????????) 8. ?a?????? ???δ??x????(???CYP3A4)?T????????Ф????a?? ??????Х?????? ?R????????÷??? ????????????p?????????????? ?C???Σ????? ????????????x????????CYP3A4???T????????????????????¤??????????? (???a???B????????) ?????? ???????k?F??r?θ?? ?y????{? ?????R????Y???????????????????????743???С????????452??(60.8??)???J?????????????????????(27.1??)????U?^??(14.8??)????????????(11.7??)?????(?????麬??)(10.5??)??????(9.6??)??????p??(9.2??)????????(6.3??)???????????(6.2??)??????????????????R???????????????CK(CPK)??N(13.7??)??????饯???????(10.9??)????ALT(GPT)??N(7.0??)????????(??????????V(????V)???J?r) ??O?????????????????θ??? ?????R????Y??????H?????Y???????????????????????192????(?????87?????)???R???????????????????144??(?????71?????)(75.0??)???J???????????????????????????(30.2??)?????(16.7??)???A??(12.5??)???ф?(10.9??)??????(10.4??)??????(9.9??)?????????(9.4??)??????(8.9??)???I??(7.8??)???????????(??o??????)(5.2??)????????(???????r) ????????????????B????????????????????J?????????????? ?????????R????Y???????????????????????467???С??R???????????????????320????68.5???????J?????????????????????????????28.1??????????????10.1????????飨9.4???????A???9.0???????????7.3??????ALT??GPT????N??7.1???????????5.6?????????????????????r?? ????????? 1. ????????????(Syndrome malin)(0.1??) ?o??}?a??????ν??????????????y???l?}????R??????k??????k?F????????????????k??????????????????????????????????a?o????????????????m?Ф?I????Ф??????????k??r?????????????????CK(CPK)????N????????????????????????????????餦?I?C????¤???????????????????????A???????R????????????y????h?????????????????I?????????Ф?????????????????? 2. ?W?k????????????(0.1??) ?L???????????????β??????\?????????????????Τ?????Τ褦?????????????????p??????????]???????????????????????????A??????????? 3. ??????w???????(0.1??) ?c????w(?????????????I??????????????????????????????????c??????Τ?????????)?????????w????????????Ф??????????Τ???c????w????????????????????????????? 4. ???????????饭???`(?l???????) ???????????饭???`????????????????Τ???Q????????Ф??????????J??????????????????????m?Ф?I????Ф?????? 5. ??????y??????(0.1??) ??y??????????????????????Τ??CK(CPK)??N????м??????Х???????????N??????????? 6. ??????????????`??????????????(?l???????) ??????????????`??????????????????????????????????????U?^????????????椵??????Τ??????????Ф??f???????????l???????????е??????k?F?????????????????Μy?????Ф?????????Q????Ф??????????J??????????????????u???????????m?Ф?I????Ф??????(??????????????? 4.??6.????????) 7. ?????(?l???????) ????????????????????Τ???????С????С??亹????顢?A??????R?????ε?????????J???????????????????????m?Ф?I????Ф??????(??????????????? 5.??6.????????) 8. ?????d??(0.4??) ?d??????????????????Τ?????????J????????????????????????m?Ф?I????Ф?????? 9. ?o?w?????(?l???????)???????p??(0.1??) ?o?w????????????p?????????????????Τ???Q????????Ф??????????J????????????????????????m?Ф?I????Ф?????? 10. ?????????????}???(?l???????) ???????????a???????????????????}????????????????椵??????Τ???Q????????Ф?????Ф???????????????????[????J?????????????????????????m?Ф?I????Ф??????(???????????????11.????????) 11. ?ΙC?????(?l???????) AST(GOT)??ALT(GPT)????-GTP??Al-P????N???餦?ΙC?????????????????????Τ???Q????????Ф??????????J????????????????????????m?Ф?I????Ф?????? ??????k?????????Τ????????J?????????? ???????θ????? 1. ??????U? 5?????? ???????U?^???????????A?? 2. ??????U? 1??5??δ?? ???????^????????????? 3. ??????U? 1??δ?? ????????`???M??????`?p?????????????????????????????????????????Z?????p??????????????????С??????U???????A?????侫?????????????????鲻???????e?????U????????d????????????????????O????????J???????????????????????悾???????w??????????????(???????????d?^)?????????????^??????d?? 4. ??????U? ?l??????? ???????????????????? 5. ?F????·?? 5?????? ??????????????? 6. ?F????·?? 1??5??δ?? ?????ф???i?Ю?????????????(??o??????)???????????????????????????????????? 7. ?F????·?? 1??δ?? ???????????????????Τ???Ф???o??????Τ?????????????`?????????????????????????k??????????? 8. ??h?? 1??5??δ?? ?????l?}??????R 9. ??h?? 1??δ?? ?????????M?????}??????R???????????R??????????(???Ⅷ?s??QT???L??) 10. ?????? 1??5??δ?? ???????????????I???????????????????????????M 11. ?????? 1??δ?? ????θ?????????θ???θ?c????c????????c??????????????????????????????[??????????θ???????????????n?????????e??? 12. ?????? ?l??????? ??? 13. ?? 1??5??δ?? ?????p????????p???????????????p????????????????p????g?????????p???????????????????????????????????? 14. ?? 1??δ?? ????????????????c????p?????c?????????????g??p????С??p????С?剈????????????N??????????????N 15. ????? 1??5??δ?? ????????饯??????????U???? 16. ????? 1??δ?? ????饯??????N 17. ??? 5?????? ALT(GPT)??N 18. ??? 1??5??δ?? AST(GOT)??N??LDH??N????-GTP??N??Al-P??N 19. ??? 1??δ?? ????????Ρ?Al-P?????LDH??????t????????N???t????????? 20. ??? ?l??????? ????????? 21. ?I? 1??5??δ?? BUN??N??BUN????????????????????? 22. ?I? 1??δ?? ???????????????N?????????????Ω`??????N???????????N??????NAG??N?????????N??????????????????p??????????p????????p?? 23. ?????? 1??5??δ?? ???? 24. ?????? 1??δ?? ?????????????????????]???l????? 25. ?????? ?l??????? ????? 26. ?^??? 1??δ?? ?????k?䴙???^?????????䴙?t??????????????? 27. ?^??? ?l??????? ?????[???n???? 28. ??w 1??δ?? ????????????w?????w?????w???????????????????? 29. ???x???? 5?????? CK(CPK)??N 30. ???x???? 1??5??δ?? ??f??????????`??????HDL-????????`????N????????饤????N???????|???? 31. ???x???? 1??δ?? ??????????????????ж??????????????????????|???x?????????????`????N??HDL-????????`????????????饤??????CK(CPK)???? 32. ???x???? ?l??????? ??Х??????? 33. ?????? 1??δ?? ????????????^???????????????d????????^????????????????? 34. ?????? ?l??????? ????????? 35. ?? 1??δ?? ?????F?????????????????{????????????????????С???? 36. ?? ?l??????? ??Υ??????? 37. ?????? 5?????? ????????p?????????? 38. ?????? 1??5??δ?? ???С??????С??k???????t????p????????????????????????????????????????????`????? 39. ?????? 1??δ?? ???????????????С????С???????????????v???????????K??????礳????d?s?????????????С?????????????b???????ē?????n?????????r?@???????????????[???????????????ζ??????????Q??????????????С??a???x??????????渡?[?????????????????t??????N??A??G??N??A??G??????????????N?????????????????????N??????????N???????`????N 40. ?????? ?l??????? ??????????????????????o????????? ??????k?????????Τ????????J?????????? ???h??????? ??????h????????C??????¤??????Τ?????????B???Q???????????????????? ?ыD???b?D??????D??????? 1. ?????ыD??????路??????????Τ???D??????????????????Σ??????????ж?????????Τ????????????????Ф??????v????????_???????????????????????????a????????????????????????????????A??????????????顢??o????????????????x???????F????·??????????????椬????????????????R????Y??????????b???椬?????? 2. ?????Ф?D??????????????????????????????????????????Ф??J????????1)???? С????????? ?????????????????????郹????????С?????????????_????????????(???U?Y???????) ?^????? ??????? ??????R????Y???????????k?????????????1,260mg?????k???????????????^???????????????????????A?????R??N???l?}???I??????????椵??????????????????????????195mg?????k?????????С????????????^??????R??????A?????????k?F???????????????????? ?I??? ????????????????????????????^?????????????????a????????????_?????????????Q???????????????Ф?????????????C??Υ????`???_???????????????}??k?F??@?A???????`??????黼?????????????????Q??????????????????????????????(???a???B????????)??????????????????????????????????????ο?????????????????????????????????? ?m???????? ?a???????r?? ???¤ε???????褦?????????? (1) ??????`???`????????????????????????PTP???`????`??????????????????????????????????????k??????????V??????????k?????????椵???????? (2) ??????`???`????????????H?????Y??Υ??`?????????????????????θ??????????????????????????????????????????????????????V?????????餫?????????`??????????????????????????????????????? (3) ???????Ф?????????????????????????`???`????????????????????Ф???????? (4) ?????????B?????????????????????? |
4楼2013-07-26 14:45:13
lunar3809
荣誉版主 (文坛精英)
禁虫
- DRDEPI: 1
- 应助: 3 (幼儿园)
- 贵宾: 0.33
- 金币: 1906.8
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★ ★
痴夷子皮: 金币+2, 感谢回帖交流，欢迎常来哦。 2013-07-31 12:53:38
痴夷子皮: 金币+2, 感谢回帖交流，欢迎常来哦。 2013-07-31 12:53:38
5楼2013-07-26 14:45:45
【答案】应助回帖
★ ★ ★ ★ ★
感谢参与，应助指数 +1
Love黑果冻(痴夷子皮代发): 金币+5, 感谢回帖交流，欢迎常来哦。 2013-07-31 12:54:49
感谢参与，应助指数 +1
Love黑果冻(痴夷子皮代发): 金币+5, 感谢回帖交流，欢迎常来哦。 2013-07-31 12:54:49
|
这里有 http://www.kegg.jp/medicus-bin/j ... ficacy.pharmacology 不知道是不是你要找的 |
6楼2013-07-26 15:14:27
lunar3809
荣誉版主 (文坛精英)
禁虫
- DRDEPI: 1
- 应助: 3 (幼儿园)
- 贵宾: 0.33
- 金币: 1906.8
- 散金: 6556
- 红花: 28
- 沙发: 96
- 帖子: 25871
- 在线: 1256.1小时
- 虫号: 696060
- 注册: 2009-02-04
- 性别: GG
- 专业: 药物化学
- 管辖: 有机交流
7楼2013-07-26 15:23:02
fengzi913
木虫 (正式写手)
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- 虫号: 2463694
- 注册: 2013-05-14
- 性别: GG
- 专业: 有机合成
【答案】应助回帖
★ ★ ★ ★ ★
感谢参与，应助指数 +1
Love黑果冻(痴夷子皮代发): 金币+5, 感谢回帖交流，欢迎常来哦。 2013-07-31 12:54:21
感谢参与，应助指数 +1
Love黑果冻(痴夷子皮代发): 金币+5, 感谢回帖交流，欢迎常来哦。 2013-07-31 12:54:21
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此为最新版说明书，PDF格式 http://www.info.pmda.go.jp/downf ... 79045F4022_1_06.pdf |
8楼2013-07-26 15:32:58
