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| The Notch ligand DLL4 is most highly expressed in endothelial tip cells, where it signals to adjacent Notch receptor-expressing endothelial cells, causing them to adopt the stalk cell fate. Reduced Notch signaling leads to increases in tip cell numbers, filopodia extension, and vessel branching. |
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andrewzhang
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°®ÓëÓêÏÂ: ½ð±Ò+1 2013-07-25 21:20:02
yin198716: ½ð±Ò+5, ·ÒëEPI+1 2013-08-03 10:50:04
°®ÓëÓêÏÂ: ½ð±Ò+1 2013-07-25 21:20:02
yin198716: ½ð±Ò+5, ·ÒëEPI+1 2013-08-03 10:50:04
| NotchÅäÌåDll4ÔÚÆ¤Ï¶Ëϸ°ûÖеıí´ï¶ÈºÜ¸ß£¬ÓɶËϸ°ûÏòNotchÐźÅÊÜÌåÏÂÆ¤Ï¸°û´«µÝÐźţ¬Ê¹ºóÕß½¥½¥³ÉΪ±úϸ°û¡£notchÐźŵļõÉٻᵼÖ¶Ëϸ°ûµÄÔö¼Ó£¬Ë¿×´Î±×ãµÄ½øÒ»²½ÑÓÕ¹£¬ÒÔ¼°Ñª¹ÜµÄ·ÖÖ§¡£ |
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