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Lewandowski

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Numerous studies show that proper levels and spatial organization of VEGF signaling is crucial to vascular development. For example, VEGF-A RNA is alternatively spliced to give multiple isoforms that differentially interact with the extracellular matrix and may set up a gradient, and disruption of this isoform balance results in abnormal vessel morphology. Flt-1 receptor RNA is also alter-natively spliced to give both a membrane-localized (mFlt-1) and a soluble (sFlt-1) isoform.Flt-1 negatively modulates VEGF signaling during devel-opment by acting as a sink for VEGF-A ligand, and spatial organization of sFlt-1 from endothelial cells is also important for correct vessel morphogenesis.
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hyt0615

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爱与雨下: 金币+1 2013-07-29 18:45:54
Lewandowski(phu_grassman代发): 金币+14, 翻译EPI+1, good Job 2013-12-03 08:42:14
大量研究表明,VEGF信号的适当水平和空间组织对血管发育至关重要。例如,VEGF-A RNA选择性剪接而产生了多种亚型,它们与细胞外基质发生不同的相互作用,然后建立一个梯度,这种亚型平衡的破坏将导致血管形态的异常。受体Flt-1的RNA也选择性剪切而产生mFlt-1和sFlt-1两种亚型。在成长过程中,Flt-1作为一个VEGF-A的配体的水槽对VEGF信号进行负调控,来自血管内皮组织细胞的sFlt-1的空间组织对正常的血管形态也同样重要。
2楼2013-07-29 12:53:39
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