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| VEGF-A also regulates sprouting angiogenesis by regulating endothelial cell phenotypes. Gerhardt et al.showed that correct vessel sprouting requires that some endothelial cells migrate in response to VEGF-A signaling and form tip cells, whereas other endothelial cells form stalk cells that primarily proliferate and lumenize. Proper vessel network formation requires the correct ratio of tip cells vs. stalk cells, and this is mediated via Notch signaling. |
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½ð³æ (³õÈëÎÄ̳)
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- Ó¦Öú: 0 (Ó×¶ùÔ°)
- ½ð±Ò: 1472.8
- Ìû×Ó: 50
- ÔÚÏß: 31.3Сʱ
- ³æºÅ: 2434650
- ×¢²á: 2013-04-24
- ÐÔ±ð: MM
- רҵ: ·ÖÎöÒÇÆ÷ÓëÊÔ¼Á
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°®ÓëÓêÏÂ: ½ð±Ò+1 2013-08-17 19:44:20
Lewandowski(phu_grassman´ú·¢): ½ð±Ò+5, ·ÒëEPI+1, thanks 2013-12-03 08:37:26
°®ÓëÓêÏÂ: ½ð±Ò+1 2013-08-17 19:44:20
Lewandowski(phu_grassman´ú·¢): ½ð±Ò+5, ·ÒëEPI+1, thanks 2013-12-03 08:37:26
| VEGF-A»¹Í¨¹ýµ÷½ÚÄÚÆ¤Ï¸°û±íÐÍÀ´µ÷½Ú·¢Ñ¿Ñª¹ÜÉú³É¡£Gerhardt µÈÑо¿±íÃ÷ÕýÈ·µÄѪ¹Ü·¢Ñ¿ÐèҪһЩÄÚÆ¤Ï¸°ûµÄÇ¨ÒÆÀ´ºôÓ¦VEGF-AµÄÐÅÁî²¢ÐÎʽ¸ù¼âϸ°û£¬¶øÄÚÆ¤Ï¸°ûÐγɵÄÖ÷ÒªÊǾßÓÐÔöÖ³ºÍlumenize¾¥Ï¸°û¡£ÕýÈ·µÄѪ¹ÜÍøµÄÐγÉÐèÒª¸ù¼âϸ°ûÓë±úϸ°ûµÄÕýÈ·±ÈÀý£¬ÕâÊÇͨ¹ýNotchÐźÅͨ·½éµ¼¡£ |
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