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| Delta and Jagged proteins are single-pass transmembrane ligands with extended extracellular domains and small intracellular domains. Five ligands in mammals act on four Notch receptors. The Notch receptors are single-pass transmembrane proteins that are proteolytically cleaved upon ligand binding. The cytoplasmic portion of the receptor then directly transduces a signal from the cell surface to the nucleus, and thus regulates expression of target genes. |
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°®ÓëÓêÏÂ: ½ð±Ò+1 2013-08-13 22:10:29
yin198716(phu_grassman´ú·¢): ½ð±Ò+5, thanks 2013-12-22 10:32:09
°®ÓëÓêÏÂ: ½ð±Ò+1 2013-08-13 22:10:29
yin198716(phu_grassman´ú·¢): ½ð±Ò+5, thanks 2013-12-22 10:32:09
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