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| Therefore, additional targets and pathways are needed to take full advantage of the anti-angiogenesis approach. One of the most fertile fields for seeking new targets has been developmental biology: embryonic development of the cardiovascular system requires a finely balanced interplay of various signalling pathways. For example, gene-targeting approaches showed that VEGF is required at an early stage of mouse vascular development, mirroring its role in tumour angiogenesis. In addition to VEGF, other signalling pathways are clearly required for different stages of normal vascular development, and these pathways are being explored as potential targets for anti-angiogenic therapies. |
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